Fighting Antibiotic Resistance
Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]
Outbreak Investigation Task Force
The recent epidemics of Lassa fever in Nigeria, Ebola virus disease in West Africa, MERS-CoV in the Middle East, Yellow Fever in DRC, Angola and Brazil, avian influenza in Asia and Africa and Zika […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
300 to 400 million cases of dengue fever occur each year worldwide. Spreading rapidly, more than 40% of the world’s population is now at risk of contracting dengue This transversal program brings together talents […]
Bacterial Infections and antibiotic Resistant Diseases among Young children in low-Income countries: an international cohort study Currently, antibiotic resistance surveillance networks and epidemiologic research focus mainly on industrialized countries. However, developing these activities […]
Pasteur International Center for Research on Emerging Infectious Diseases
We established an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one-health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. We built on […]
The European Virus Archive Goes Global
EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]
Mobile nucleic acid testing of asymptomatic Plasmodium infections for malaria elimination
Increased international malaria control efforts have resulted in dramatic reduction in the global malaria incidence over the past decade. In some places, the efficiency of control measures has led to the thought that elimination […]
ACIP 275 – SURVEV68: Enterovirus 68 investigation in children with acute respiratory infection and acute flaccid myelitis in two Subsaharan african countries
Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]
Role of mosquito saliva in the transmission of Rift Valley fever virus
State of the art and objectives Traditional means of controlling arbovirus diseases include vaccination of susceptible vertebrates and mosquito control, but in many cases these have been unavailable or ineffective. The increased disease […]
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
NéoVac (Neonatal Vaccination against Hepatitis B in Africa)
Chronic infection with hepatitis B virus (HBV) is an important cause of premature adult deaths in sub-Saharan Africa (SSA), due to liver cancer or cirrhosis. To reduce the disease burden, it is critical to […]
Effect of host-parasite interaction on the outcome of malaria infection
It is well accepted that the outcome of infection in malaria depends upon interaction between the human host and Plasmodium spp. This is the result of forces of selection and escape acting on the […]
Enterovirus A 71 (EV-A71) is an emerging pathogen that is circulating worldwide and mostly causes hand, foot, and mouth disease (HFMD) in children. However, in many cases, EV-A71 causes neurological complications, such as meningitis, […]
Community-based home visit intervention in sub-Saharan Africa to improve Hepatitis B vaccination coverage at birth and neonatal survival (Neovac)
The aim of this study is to develop and evaluate a community-based home visit intervention in sub-Saharan Africa to improve the coverage of a timely birth dose of HBV vaccine and neonatal care practices […]
Population biology of the bacterial pathogen Klebsiella pneumoniae
Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics. In this project we aim to understand the ecological, epidemiological and […]
Deciphering the impact of Plasmodium/Trypanosoma co-infections on the vectorial capacity of Anopheles mosquitoes. Malaria and African trypanosomiasis (AT), also known as sleeping sickness in humans and Nagana in cattle, are two parasitic diseases prevalent […]
Alerting and Surveillance for Infectious Disease Epidemics
In a context of increasing globalization of trade, the growth in international flows of travelers and goods fuels the spread of infectious diseases. The need for a global alert and response network for infectious diseases […]
2020Development of a New Internally Controlled One-Step Real-Time RT-PCR for the Molecular Detection of Enterovirus A71 in Africa and Madagascar., Front Microbiol 2020 ; 11(): 1907.
2018Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa, J. Hepatol. 2018 Jun;.
2018Poor Sensitivity of Commercial Rapid Diagnostic Tests for Hepatitis B e Antigen in Senegal, West Africa, Am. J. Trop. Med. Hyg. 2018 Aug;99(2):428-434.
2018Genetic Characterization of Enterovirus A71 Circulating in Africa., Emerging Infect. Dis. 2018 04; 24(4): 754-757.
2017Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa, N. Engl. J. Med. 2017 04;376(15):1483-1485.
2016High third-generation cephalosporin resistant Enterobacteriaceae prevalence rate among neonatal infections in Dakar, Senegal., BMC Infect Dis. 2016 Oct 20;16(1):587..
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