Yves Jacob

Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]

Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]

As a major pathway of reversible protein modification in eukaryotes cells, leading to their degradation, affecting their subcellular localization, or activity, the Ubiquitin Proteasome System (UPS) is a prime target of viruses. Recent evidence […]

Despite medical progress, the recent outbreaks of viral zoonoses (e.g. MERS-CoV, Ebola virus disease) illustrate the constant threat represented by viruses in a world in motion and globalization. These epidemic events stress the need […]

To date, knowledge on the interaction network between filovirus proteins and the host proteome (virhostome) are still extremely small and fragmented. These studies are limited to a few proteins such as VP24, VP35 and […]

The use of light from the abyss in life sciences   In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]

we developed an optogenetic “Cre-stiching” strategy for barcode fusion genetics. This new technology is based on light-inducible Cre-recombinase complementation. The resulting optogenetic control Cre-recombinase produces a concatenated DNA, linking together genetic barcodes. These concatenated […]

The coverage and robustness of protein-protein interactions (PPI) datasets can be markedly increased by combining orthogonal PPI assays. For this purpose we have recently developed two variations of our High-throughput Gaussia princeps Complementation Assay(HT-GPCA), […]