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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
3 Members

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

Nicolas Wolff (PI)

Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Project
Ongoing
6 Members

Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle

Nathalie Pardigon (PI)

Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
Project
Ongoing
4 Members

Interplay between influenza virus and the ubiquitin/proteasome system

Caroline Demeret (PI)

As a major pathway of reversible protein modification in eukaryotes cells, leading to their degradation, affecting their subcellular localization, or activity, the Ubiquitin Proteasome System (UPS) is a prime target of viruses. Recent evidence […]
Project
Ongoing
2 Members

Multi-species mapping of influenza viruses cellular targets using high-throughput complementary strategies in a “One Health” perspective.

Yves Jacob (PI)

Despite medical progress, the recent outbreaks of viral zoonoses (e.g. MERS-CoV, Ebola virus disease) illustrate the constant threat represented by viruses in a world in motion and globalization. These epidemic events stress the need […]
Project
Ongoing
4 Members

Comparative interactomics of filoviridae (Task Force Ebola WP6.2)

Yves Jacob (PI)

To date, knowledge on the interaction network between filovirus proteins and the host proteome (virhostome) are still extremely small and fragmented. These studies are limited to a few proteins such as VP24, VP35 and […]
Project
Ongoing
12 Members

Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions

Yves Janin (PI)

The use of light from the abyss in life sciences   In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]

Tools

Tool
Ongoing
2 Members

Optogenetic “Cre-stiching” strategy for barcode fusion genetics

Yves Jacob (PI)

we developed an optogenetic “Cre-stiching” strategy for barcode fusion genetics. This new technology is based on light-inducible Cre-recombinase complementation. The resulting optogenetic control Cre-recombinase produces a concatenated DNA, linking together genetic barcodes. These concatenated […]
Tool
Ongoing
5 Members

High-throughput protein-protein interaction assay based on a split-luciferase

Yves Jacob (PI)

The coverage and robustness of protein-protein interactions (PPI) datasets can be markedly increased by combining orthogonal PPI assays. For this purpose we have recently developed two variations of our High-throughput Gaussia princeps Complementation Assay(HT-GPCA), […]

Publications

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