Inhibitors of Pseudomonas aeruginosa IMPDH
IMPDH from Pseudomonas aeruginosa (see Inosine-5′-monophosphate dehydrogenase project) was found to be allosterically regulated by MgATP (Labesse et al., 2013). The discovery of this mode of regulation of the catalytic activity, never described before […]
Inosine-5′-monophosphate dehydrogenase (IMPDH) is ubiquitously essential for the biosynthesis of guanosine nucleotides and catalyzes the NAD-dependent oxidation of IMP to XMP. IMPDH is a major target in the design of both antitumor and immunosuppresive […]
2015Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
2015Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties, PLoS ONE 2015;10(2):e0116578.
2013MgATP regulates allostery and fiber formation in IMPDHs, Structure 2013 Jun;21(6):975-85.