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About

My project in the lab is to understand the developmental origin of craniofacial muscles especially muscles of mastication, deglutition and peristalsis viz. muscles of the esophagus. We discovered that the Esophagus Striated Muscles (ESM) are not derived from somites as generally thought, but are of cranial mesoderm origin. We identified Tbx1 and Isl1 as the key regulators of ESM which is a novel third derivative of the cardiopharyngeal mesoderm that also contributes to head muscles and derivatives of the second heart field.

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