Sandra Pellegrini is Director of Research INSERM and Head of the Unit of Cytokine Signaling at the Institut Pasteur in Paris. After graduating with a Laurea in Biological Sciences at the University La Sapienza in Rome (Italy), she obtained a Ph.D in Basic Medical Sciences from New York University, New York (USA) in 1986. Following a post-doctoral training at the Imperial Cancer Research Fund, London (UK), she joined the Institut Pasteur. Since 2002, she heads a research unit in the Department of Immunology investigating molecular mechanisms underlying the pleiotropic action of type I interferons.
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2022IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation., Front Immunol 2022 ; 13(): 939907.
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2021Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency., J Clin Invest 2021 Jan; 131(1): .
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2021Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment., Front Immunol 2021 ; 12(): 628375.
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2020An Old Cytokine Against a New Virus?, J Interferon Cytokine Res 2020 08; 40(8): 425-428.
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2020COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death., Cancer Lett 2020 04; 476(): 106-119.
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2020Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
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2020Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21., Front Genet 2020 ; 11(): 627007.
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2019USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression, Sci Rep 2019 Mar;9(1):4066.
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2018Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant, Sci Immunol 2018 Dec;3(30).
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2018Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds, PLoS ONE 2018;13(10):e0205826.
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