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© Research
Member: Head of Structure

Sandra Pellegrini

• Cytokine Signaling

Laboratory: Cytokine Signaling

About

Sandra Pellegrini is Director of Research INSERM and Head of the Unit of Cytokine Signaling at the Institut Pasteur in Paris. After graduating with a Laurea in Biological Sciences at the University La Sapienza in Rome (Italy), she obtained a Ph.D in Basic Medical Sciences from New York University, New York (USA) in 1986. Following a post-doctoral training at the Imperial Cancer Research Fund, London (UK), she joined the Institut Pasteur. Since 2002, she heads a research unit in the Department of Immunology investigating molecular mechanisms underlying the pleiotropic action of type I interferons. 

Projects

Project
Ongoing
3 Members

TYK2 variants in cytokine signaling and autoimmune diseases

Sandra Pellegrini (PI)

TYK2 belongs to the Janus/JAK family of protein tyrosine kinases and is involved in signaling of immunoregulatory cytokines (type I and type III IFNs, IL-6, IL-10 and IL-12 families) that contribute to a balanced […]
Project
Ongoing
2 Members

IFN-I and translational control

Sandra Pellegrini (PI)

We have investigated whether IFN-I activates the mTOR translational control pathway and to what extent the control of mRNA translation contributes to IFN α2/β responses. General questions have been addressed by a genome-wide search […]
Project
Ongoing
2 Members

Exploring a link between ISGylation and cell cycle via SKP2

Sandra Pellegrini (PI)

We recently uncovered a potentially interesting connection between ISGylation and cell cycle regulation. We reported that the degradation of USP18, major negative regulator of IFN-I signaling, involves SKP2, a well known actor in cell […]
Project
Ongoing
2 Members

ISG15 contribution to tuning of IFN-I activity and interferonopathies

Sandra Pellegrini (PI)

We have reported on the implication of the ubiquitin-like ISG15 protein in the negative regulation of IFN-I response in humans. ISGylation is a major post-translational modification whereby numerous proteins are conjugated to ISG15, with […]
Project
Ongoing
2 Members

Fine-tuning of IFN-I response by USP18

Sandra Pellegrini (PI)

The type I IFN system needs to be regulated not only at the level of its production, but also at the level of responses. We have shown that cells that have responded to IFN-I […]

Publications

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