Sandra Pellegrini is Director of Research INSERM and Head of the Unit of Cytokine Signaling at the Institut Pasteur in Paris. After graduating with a Laurea in Biological Sciences at the University La Sapienza in Rome (Italy), she obtained a Ph.D in Basic Medical Sciences from New York University, New York (USA) in 1986. Following a post-doctoral training at the Imperial Cancer Research Fund, London (UK), she joined the Institut Pasteur. Since 2002, she heads a research unit in the Department of Immunology investigating molecular mechanisms underlying the pleiotropic action of type I interferons.
TYK2 variants in cytokine signaling and autoimmune diseases
TYK2 belongs to the Janus/JAK family of protein tyrosine kinases and is involved in signaling of immunoregulatory cytokines (type I and type III IFNs, IL-6, IL-10 and IL-12 families) that contribute to a balanced […]
IFN-I and translational control
We have investigated whether IFN-I activates the mTOR translational control pathway and to what extent the control of mRNA translation contributes to IFN α2/β responses. General questions have been addressed by a genome-wide search […]
Exploring a link between ISGylation and cell cycle via SKP2
We recently uncovered a potentially interesting connection between ISGylation and cell cycle regulation. We reported that the degradation of USP18, major negative regulator of IFN-I signaling, involves SKP2, a well known actor in cell […]
ISG15 contribution to tuning of IFN-I activity and interferonopathies
We have reported on the implication of the ubiquitin-like ISG15 protein in the negative regulation of IFN-I response in humans. ISGylation is a major post-translational modification whereby numerous proteins are conjugated to ISG15, with […]
2020Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage, PLoS ONE 2020;15(1):e0225289.
2019USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression, Sci Rep 2019 Mar;9(1):4066.
2018Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant, Sci Immunol 2018 Dec;3(30).
2018Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds, PLoS ONE 2018;13(10):e0205826.
2017Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors, J. Leukoc. Biol. 2017 05;101(5):1181-1190.
2017STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling, Nat. Struct. Mol. Biol. 2017 Mar;24(3):279-289.
2016Mycolactone subverts immunity by selectively blocking the Sec61 translocon, J. Exp. Med. 2016 Dec;213(13):2885-2896.
2016Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome, J. Exp. Med. 2016 Jun;213(7):1163-74.
2016ISG15 deficiency and increased viral resistance in humans but not mice, Nat Commun 2016 05;7:11496.
2016The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells, Biol. Direct 2016;11:21.
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