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A synthetic glycopeptide for anti-tumor immunotherapy: from design to first use in human
Sylvie Bay (PI)
Within the framework of developing a carbohydrate-based vaccine against cancer, we designed and prepared the MAG-Tn3, a fully synthetic immunogen based on the tumor-associated Tn antigen. The MAG-Tn3 is a glycopeptide associating Tn clusters […]
2018Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors, Cell Rep 2018 Apr;23(4):1072-1084.
2016Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate, Org. Biomol. Chem. 2016 Dec;15(1):114-123.
2014CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus, Sci Transl Med 2014 May;6(238):238ra72.
2014Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings, J. Infect. Dis. 2014 Aug;210(3):424-34.
2013Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses, PLoS ONE 2013;8(1):e52003.
2011Regulatory B cells control dendritic cell functions, Immunotherapy 2011 Apr;3(4 Suppl):19-20.
2010Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses, J. Biol. Chem. 2011 Mar;286(10):7797-811.
2010Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant, Blood 2010 Nov;116(18):3526-36.
2009Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils, Immunity 2009 Nov;31(5):761-71.
2009Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide, ChemMedChem 2009 Apr;4(4):582-7.
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