Matthew Albert is Director of Research INSERM and Head of the Laboratory of Dendritic Cell Immunobiology at the Institut Pasteur, Paris, leading a team in the area of dendritic cell immunobiology and tumor immunity. He graduated from Brown University, Providence, RI, USA in 1992 with a B.Sc in Chemistry, followed by a Ph.D in Immunology from The Rockefeller University, New York, USA, in 1999 and M.D. in Medicine from Cornell University Medical College, New York, USA, in 2000.
9th HKU-Pasteur Immunology Course: March 19-31, 2017
The general theme of this year’s course will be Quantitative Immunology to explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, to a more integrated view […]
The Healthy Human Global Project
Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]
Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Defining the regulation of antigen cross-priming and T cell effector function
The objective of this work is to characterize the requirements for the induction of antigen specific T cells. Classically, it was believed that antigen presentation on molecules of the class I major histo-compatibility complex […]
DPP IV and cancer immunotherapy
Dipeptidylepeptidase 4 (DPP4) is a transmembrane glycoprotein expressed by hepatocytes, kidney epithelium and various tissue endothelium. In the immune system, DPP4 is expressed on B, T and NK cells. Additionally, DPP4 expression may be […]
Biomarker discovery and viral disease pathogenesis
Biomarker discoveryWe are interested in the discovery of biomarkers that can be used to guide the clinical management of patients, and can also inform us about basic disease pathogenesis. The lab’s interest in this […]
Milieu Intérieur: Deconvolution of the healthy immune response
Systems approaches for the study of immune signaling pathways have been traditionally based on selected purified cell types or cultured cell lines. However, in vivo responses involve the coordinated action of multiple cell types, […]
Functional immune response to Mycobacteria tuberculosis derived antigen
The objective of our project is to establish feasibility for a new generation of in vitro diagnostic (IVDs) tools, applied to proof-of-concept studies in Mycobacterium tuberculosis (MTB) infected persons and patients with TB disease. […]
1,000 healthy donors
The Milieu Intérieur Consortium has established a 1000-person healthy population-basedstudy (stratified according to sex and age), creating an unparalleled opportunity for assessing thedeterminants of human immunologic variance. The Milieu Intérieur Consortium initiated in September […]
Ac Mong Virus Encephalitis (AVE) Project: Investigation of unexplained acute encephalitis outbreaks in Northern Vietnam
(Collaborators: Phan Thi Nga, Hanoi; Paul Brey, IP Vientiane; Jean-Claude Manuguerra, Antoine Gessain, Marc Eloit, Matthew Albert, Olivier Lortholary, Juliette Paireau, Arnaud Fontanet, IP Paris).Funding : ANR, Geneviève Deyme, BNP Paribas Simplidons, ACIP.More than […]
Towards a better understanding and treatment of childhood malnutrition in the developing world
Description: PEE and malnutrition are complex syndromes, reflecting a plethora of diverse environmental influences. To tackle this complexity, the Afribiota project brings together a broad range of multi-disciplinary approaches: epidemiology, anthropology, microbiology, immunology and […]
2017Dying cells actively regulate adaptive immune responses, Nat. Rev. Immunol. 2017 Mar;.
2017Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents, J. Virol. 2017 03;91(6).
2016Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations, Cell 2016 Oct;167(3):643-656.e17.
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.011 show.
2016Bladder catheterization increases susceptibility to infection that can be prevented by prophylactic antibiotic treatment., JCI Insight. 2016;1(15):e88178.
2016Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses, J. Virol. 2016 Nov;90(21):9683-9692.
2016Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset, PLoS Pathog. 2016 Aug;12(8):e1005774.
2016Comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”, Sci Transl Med 2016 Jul;8(349):349le1.
2016Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies, EMBO Mol Med 2016 Jun;8(6):679-83.
2016Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis, BMC Infect. Dis. 2016;16:138.
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