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© Michaela Muller-Trutwin
HIV

About

Dr. Mathieu Angin received his PhD in Immunology in 2008 from the University of Nantes, France. During his training at the Center of Research in Transplantation and Immunology, he worked on the induction of tolerance in transplantation through T cell costimulatory blockade under the  supervision of Dr. Brigitte Le Mauff. In 2009, he joined the group of Dr. Marylyn Addo at the Ragon Institute of MGH, MIT and Harvard in Boston, USA. There he worked as a post-doctoral fellow for 5 years on the understudied but important role of regulatory T cells in the context of HIV-1.

In 2014, he came back to France to work as a post-doctoral fellow at the Institut Pasteur in the team of Dr. Asier Saez-Cirion to work on the characterization of HIV-1 specific CD8+ T cell gene expression profiles in HIV controllers with the help of the French research agency ANRS. Thanks to a Marie Skłodowska-Curie Individual Fellowship from the European Commission and the support of SIDACTION, he investigated the role of metabolism in the control of HIV infection by CD8+ T cells. Understanding the mechanisms leading to an efficient CD8+ T cell response against the virus could lead to the development of new pharmacological tools to develop controller-like responses in HIV-infected progressors.

ANRS_COUL logo_ce-en-rvb-hrLogo_Sidaction

Projects

CV

(EN)

March 2014 – Feb. 2018. Senior post-doctoral research fellow at the Institut Pasteur of Paris, France. HIV, Inflammation and Persistence Research Unit.
– Characterization of memory HIV-specific CD8+ T cell responses in HIV controllers.
– Role of metabolism in the control of HIV infection by CD8+ T cells.
Mentor: Dr. Asier Saez-Cirion.

Previous positions and professional experiences
Feb. 2009 – Jan. 2014. Post-doctoral research fellow at the Ragon Institute of MGH, MIT and Harvard. Boston, MA, USA.
Studies on the impact of regulatory T cells on HIV-1 infection and immunopathogenesis.
Mentor: Dr. Marylyn Addo.

Oct. 2004 – Dec. 2008. PhD training at the Center of Research in Transplantation and Immunology. Nantes, France.
Studies on the induction of tolerance in transplantation through blockade of CD40/CD40L: Characterization of tolerogenic cells induced in a rat model and evaluation in the primate.
Mentor: Dr. Brigitte Le Mauff.

Jul. 2003 – Jul. 2004. Master’s degree training at the Center of Research in Transplantation & Immunology. Nantes, France.
Studies on production of insulin secreting cells from murine embryonic stem cells.
Mentor: Dr. Brigitte Le Mauff.

Jan. – Apr. 2003. Training at the Gene Therapy Laboratory (now Atlantic Gene Therapies) in Nantes, France.
Characterization of oval cells and in vitro gene transfert.
Mentor: Dr. Nicolas Ferry

Education
2008. PhD in Immunology. University of Nantes, France
2004. Master in “Bases fondamentales des Nouvelles thérapies cellulaires et moléculaires”. Université Paris-Est Val de Marne.

Publications

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