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About

The bioinformatics of virus evolution and adaptation (PhD project)

Marie Morel PhD project (funded by INCEPTION – supervision O. Gascuel and E. Simon-Lorière – FIRE doctoral school) aims at understanding how the various environment in which a virus might multiply can influence its evolutionary trajectories. This question is studied using statistical and computational methods under two main angles: 1) identification of signs of adaptation at the sequence level in large datasets, and 2) study of the dynamic of viral population in terms of composition and diversity. She is developing a simulation method to detect and assess convergent substitutions, which are one of the consequences of selection pressure on the viral sequence. She is also studying the evolution of minor variants in the intra-host diversity when viruses are submitted to drug treatment. The studied organisms for this project are HIV and HCV, both treated with antiviral drugs and responsible for millions of infections worldwide.

Courses

Evolution and Phylogenetics – Institut Pasteur Tunis

This introductory course aims to give the basic theoretical and practical concepts, best practices, and software necessary to start working on molecular phylogenetics and its applications to epidemiology. The course is a part of […]

2020-12-02 09:00:00 2020-11-06 18:00:00 Europe/Paris Evolution and Phylogenetics – Institut Pasteur Tunis This introductory course aims to give the basic theoretical and practical concepts, best practices, and software necessary to start working on molecular phylogenetics and its applications to epidemiology. The course is a part of […] Institut Pasteur، Tunis, Tunisia

CV

Education

PhD Student, Evolutionary bioinformatics and genomics, Institut Pasteur Paris, 2018–2021
Ingénieure agronome specialized in computational biology, INP-ENSAT Toulouse , 2014–2017
Concours au grandes écoles – Biology chemistry physics geology,  Lycée Thiers, Marseille, 2012–2014

Research experience

Graduate researcher in bioinformatics,  EMBL-EBI, Hinxton UK,  2017
Graduate researcher in life sciences, LRSV Toulouse, 2016