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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Member: Associate Professor - Alumni

Luis Graca

Scientific Fields
Diseases
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Connections

CV

EDUCATION / QUALIFICATIONS :

  • 2010             Habilitation  University of Lisbon, Portugal
  • 2003             DPhil in Immunology (under Herman Waldmann) University of Oxford, UK
  • 1995             Medical Degree (M.D.) University of Lisbon, Portugal

POSITIONS HELD :

2013 – Associate Professor Faculty of Medicine, University of Lisbon, Portugal
2005 – Head of research group Instituto de Medicina Molecular, Lisbon, Portugal
2005 – 2013 Assistant Professor Faculty of Medicine, University of Lisbon, Portugal
2004 – 2005 Post-doctoral fellow Patrick G. Holt group University of Western Australia, Perth, Australia Telethon Institute for Child Health Research
2002 – 2004 Post-doctoral fellow University of Oxford, UK
 1999 – 2002 PhD student Herman Waldmann group University of Oxford, UK Sir William Dunn School of Pathology
1996 -1997 Medical internship Hospital Santa Maria, Lisbon, Portugal

HONORS AND AWARDS :

  • 2011   Award in Autoimmunity Research NEDAI, Portuguese Society of Internal Medicine
  • 2010  Venture Competition Award             ISCTE-IUL MIT-Portugal Venture Competition
  • 2010   Young Entrepreneur Award                National Society of Entrepreneurship (ANJE)
  • 2010   National Innovation Award for Health Technologies; Espirito Santo Bank (BES)
  • 2009   Professor Heimburger Award in Coagulation Diseases; CSL – Behring, Germany
  • 2002-04  Junior Research Fellowship              Wolfson College, University of Oxford, UK
  • 1995   Clinical Research Prize                         Society of Medical Sciences / Pfizer Several Travel Awards (FOCIS, EFIS, Keystone Symposium), and best-poster awards.

PUBLICATIONS (10 selected publications) : 1. Fonseca VR, Agua-Doce A, Maceiras AR, Pierson W, Ribeiro F, Romão VC, Pires AR, Silva SL, Fonseca JE, Sousa AE, Linterman MA, Graca L (2017) Human blood CXCR5+Foxp3+ T cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Sci Immunol. 2, eaan1487. 2. Maceiras R, Almeida SCP, Mariotti-Ferrandiz E, Chaara W, Jebbawi F, Six A, Hori S, Klatzmann D, Faro J, Graca L (2017) T follicular helper and T follicular regulatory cells from the same germinal centers have different TCR-specificity. Nature Commun. 8:15067. 3. Maceiras AR, Fonseca VR, Agua-Doce A, Graca L (2017) T follicular regulatory cells in mice and m Immunology. 152: 25-35. 4. Monteiro M, Agua-Doce A, Almeida CF, Fonseca-Pereira D, Veiga-Fernandes H, Graca L (2015) IL-9 expression by invariante NKT cells is not imprinted during thymic development. J Immunol. 195: 3463-3471. 5. Oliveira VG, Agua-Doce A, Curotto de Lafaille M, Lafaille JJ, Graca L. (2013) Adjuvant facilitates anti-CD4 mediated immune tolerance to recombinant factor VIII in hemophilia through a Foxp3-independent mechanism that relies on IL-10. Blood 121: 3938-3945. 6. Monteiro M, Almeida CF, Agua-Doce A, Graca L. (2013) Induced IL-17-producing invariant Natural Killer T cells require activation in presence of TGF-β. J Immunol 190: 805-811. 7. Duarte J, Carrié N, Oliveira VG, Almeida C, Agua-Doce A, Rodrigues L, Simas P, Mars LT, Graca L. (2012) T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4-blockade in experimental autoimmune encephalomyeliti J Immunol 189:1680-1688. 8. Wollenberg I, Agua-Doce A, Hernández A, Almeida C, Oliveira V, Faro J, Graca L. (2011) Regulation of germinal centre reaction by Foxp3+ follicular regulatory T c J Immunol 187: 4553-4560. 9. Oliveira VG, Paiva RS, Demengeot J, Graca L. (2011) Sub-optimal CD4 T cell activation triggers TGF-β-dependent conversion to Foxp3+ regulatory T cells Eur J Immunol 41:1249-55. 10.Monteiro M, Almeida CF, Caridade M, Ribot JC, Duarte J, Agua-Doce A, Wollenberg I, Silva- Santos B, Graca L. (2010) Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF-β. J Immunol 185: 2157-2163. INSTITUTIONAL RESPONSIBILITIES :

  • 2017-     Member of the Scientific Council, Faculdade de Medicina, Universidade de Lisboa
  • 2016-     Member of the Academic Council, Faculdade de Medicina, Universidade de Lisboa
  • 2013-     Member of the board of the IMM PhD Program (Lisbon BioMed)
  • 2016-     Member of the General Assembly of IMM (in representation of the researchers)
  • 2014-17 Member of Conselho de Escola (Supervisory Council), Fac. Medicina, Univ. Lisboa
  • 2009-14 Member of the Scientific Council, Faculdade de Medicina, Universidade de Lisboa
  • 2010-     Member of the scientific committee of the rodent facility at the IMM
  • 2014-17  Head of the users committee of the Flow Cytometry unit at the IMM
  • 2006-08  Organizer of the external seminar series at the IMM

COMMISSIONS OF TRUST :

2013-16 Board of scientific counsilors for Health Sciences Portuguese Research Council (Fundação para a Ciência e Tecnologia, FCT), Portugal
2015- President Portuguese Society for Immunology
2012- Board of Directors Portuguese Society for Immunology
2017- President Sociedade de Ciências Médicas de Lisboa
2006- Board of Directors Sociedade de Ciências Médicas de Lisboa

Reviewer for scientific journals including: American Journal of Transplantation, Blood, Clinical Cancer Research, European Journal of Immunology, FEBS Letters, Genes & Immunity, Journal of Clinical Investigations, Journal of Experimental Medicine, Journal of Immunology, Nature Immunology, PNAS, Science Immunology, Trends in Immunology, Trends in Molecular Medicine. Associate Editor: Journal of Immunology; PLoS One; Frontiers in Immunology (section Immune Tolerance). Reviewed research grants for: ERC (European Research Council); AICR (Association for International Cancer Research), UK; Arthritis Research UK; Fondation pour la Reserche Medicale, France; ARSEP, France; Katholieke Universiteit Leuven, Belgium; Landsteiner Foundation, Netherlands; NHMRC (National Health and Medical Research Council), Australia; and fellowship applications for FCT (Fundacao para Ciencia e Tecnologia), Portugal. INVITATION FOR ORAL COMMUNICATIONS IN MEETINGS : Invited speaker at conferences in Austria, Brazil, France, Germany, Hong Kong, Portugal, Spain, UK, USA; academic institutions (Australia, Austria, Belgium, Brazil, China, France, Germany, Portugal, UK, USA), and biotech companies (Germany, UK, USA). Furthermore, work from groupmembers has been regularly selected for oral communications in major conferences, and awarded prizes (i.e. travel awards, best presentation, best poster). Co-organizer of international conferences: New Trends in Immunotherapy, Montpellier 2011; and Madrid 2012; Co-chair of 8th European Workshop on Immune-Mediated Inflammatory Diseases (IMID), Funchal 2014.