Mechanism of ageing and progeroid diseases
The mechanisms governing ageing, which is a multifactorial process, have not been resolved and constitute a fundamental open question in cell and organismal biology. Ageing is dramatically accelerated in some rare genetic disorders. Dissecting […]
Microglial role in the septic associated encephalopathy
Understanding the role of the microglial cells in the septic associated encephalopathy and the impact of molecular modulation.
Date of Birth: 05/05/1979, France.
2001-2002 Master 2 Biology Health – Medical, Université Bordeaux 2, UMR5200, CNRS
2000-2001 Maîtrise Cellular Biology and Physiology, Université Bordeaux 2, Medicine Faculty
1999-2000 Licence Cellular Biology and Physiology, Université Bordeaux 2, Medicine Faculty
1998-1999 DEUG Cellular Biology and Physiology, Univeristé Bordeaux 1
Research and professional experience:
From October 2015 CR1 CNRS Group Dr. Miria Ricchetti, Stability of Nuclear and Mitochondrial DNA, Unit of Stem Cells & Development, Dept. of developmental and Stem cell biology, and UMR 3525 CNRS, Dept. of Genomes and Genetic
October 2011 – September 2015 CR2 CNRS Group Dr. Miria Ricchetti, Stability of Nuclear and Mitochondrial DNA, Unit of Stem Cells & development, Dept. of Developmental and Stem Cell Biology, and UMR3525 CNRS, Dept. of Genomes and Genetic
June 2007- Sept. 2011 Post-doc. Team Dr. Miria Ricchetti. Institut Pasteur
Immunology dep. then CNRS URA2171 (Dir. Prof. B. Dujon) then UMR3525 (Dir. Dr. A. Jacquier)
PTR Funding (2007-2008); Bourse Roux (2009-2010); Mécénat Mr. François René Lacoste (2011)
Jan. 2006- April 2007 Post-doc. Prof. Federica Brandizzi, NSERC, U. of Saskatchewan, Canada.
Sept. 2002- Dec. 2005 Ph.D Biology Health-Medical. Thesis, U. Bordeaux 2, Bordeaux
UMR5200, CNRS (Thesis Supervisor : Dr. Patrick Moreau) Collaborations: Oxford Brookes U., RSBMS (Prof. Chris Hawes), UK; U. of Saskatchewan (Prof. Federica Brandizzi), Canada
2004 Alliance Egide Contract. Prof. Chris Hawes, Oxford Brookes University, Oxford,UK
2005 Award of the Gouvernment of Canada. Prof. Federica Brandizzi, U.of Saskatchewan, Canada
2007 Qualified « Maitre de Conférence »: Sections 65 Cellular Biology and 66 Physiology
April 2008 2nd Price Concours Image 2008, Imagopole PFID, Institut Pasteur
Correspondant Information Communication UMR3525 CNRS
2016A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity, Methods Mol. Biol. 2016;1351:49-65.
2015Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy, Nat Commun 2015;6:10145.
2015Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice, Shock 2015 Sep;44(3):245-51.
2015Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome, Proc. Natl. Acad. Sci. U.S.A. 2015 Jun;112(22):E2910-9.
2015mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution, Methods Mol. Biol. 2015;1264:133-47.
2014Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene, Antioxid. Redox Signal. 2014 Aug;21(6):819-34.
2014Are mitochondria the Achilles’ heel of the Kingdom Fungi?, Curr. Opin. Microbiol. 2014 Aug;20:49-54.
2013Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle, Nucleic Acids Res. 2013 Mar;41(5):3068-78.
2012Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging, J. Cell. Sci. 2013 Feb;126(Pt 4):914-26.
2012Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity, Nat Commun 2012;3:903.
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