During his PhD at the Institut Pasteur (Dr. Nancy Guillén’s lab), Julien studied the molecular biology of Entamoeba histolytica, the agent of amoebiasis. He developed RNAi methods to knockdown gene expression in this protozoan parasite as well as a diagnosis tool for the detection of intestinal amoebiasis. His thesis won a special award from the Société Française de Parasitologie. After defending his PhD in 2008, Julien chose to go on with the study of host-parasite interactions, focusing on the immunology of Chagas disease. He joined Pr. Fresno’s lab at the CBMSO (Madrid, Spain) for a first post-doc, where he used Trypanosoma cruzi as a model to investigate about the bittersweet dialogue between the parasite and the host. The modulation of the immune system impacting both parasite and host survival was studied both in vivo and in vitro. Julien joined the lab in September 2012 thanks to an FRM post-doctoral fellowship. Until December 2014 he studied the mechanisms controlling protein import in the flagellum. Julien next moved to Toulouse to work on Toxoplasma in Nicolas Blanchard’s lab within the ParaFrap Labex. He has now founded his own company called Science and Healthcare for Oral Welfare.
2015Imaging intraflagellar transport in trypanosomes, Methods Cell Biol. 2015;127:487-508.
2014Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes, PLoS ONE 2014;9(12):e115893.
2014Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics, Mol. Cell Proteomics 2014 Jul;13(7):1769-86.