Mammalian SD is a balance of mutually antagonistic pathways
Our data on the role of nuclear receptors in human ovarian development and the repression of WNT signaling during mammalian testis formation suggests the main function of pro-testis genes may be to antagonize pro-ovary […]
Control of expression of the human testis-determining gene SRY.
Cell fate decisions requiring appropriate transcriptional regulation key genes. SRY is pivotal in mammalian SD but how the expression of SRY is regulated in mammals is unknown. We identified a family from central India […]
Cellular reprogramming to understand human sex-determination.
A major gap in the field is the lack of appropriate cellular models to study human SD. This is particularly pressing since we are identifying differences between the human and mouse SD systems. We […]
Identification of key components of the human sex-determination pathway. The DSD exome/genome project.
Disorders/differences in Sex Development (DSD) are defined as congenital conditions with discordant development of chromosomal and gonadal/anatomical sex and cover a wide range of phenotypes that involve the endocrine and reproductive systems. In the […]