Notch Meeting XI
Patterning dynamics by Notch (Corson et al., Science, 2017)
Adult flies exhibit five rows of regularly spaced Sensory bristles on either side of the dorsal midline (E). Each bristle emerge from a Sensory Organ Precursor cell (SOP) during development (A-D).
An initial bimodal gradient of Delta activates Notch (GFP-E(split)m3, green, a direct early target of Notch) in intermediate levels of Delta (A). Activated Notch serves as negative template for Delta and proneural gene (Achaete and Scute) expression (B). Cells that express proneural genes are endowed with the competence to acquire the SOP fate. SOPs are singled out via the progressive decimation of the stripes (C). During this process, cells becoming SOPs (Senseless marker) send a strong inhibitory signal to neighboring cells which activate Notch receptor and prevent them from adopting the SOP fate (D).