Centrosome dissection of T. gondii
We propose to focus on deciphering the mechanistic underpinnings of intracellular replication, as a prominent source of pathogenesis. In particular, given its fundamental role in orchestrating central events to apicomplexan cell division, and flagellar […]
Molecular bases for the role of IFT172 in ciliogenesis and in ciliopathy
The cilium is an important organelle for motility and cellular signaling found on most mammalian cells and on single celled organisms such as the parasite Trypanosoma brucei. Cilia formation requires the process of Intraflagellar […]
Jamin performed his PhD at the University of Würzburg, Germany, in the group of Markus Engstler where he investigated the duplication and biogenesis of organelles in the parasite Trypanosoma brucei and its relevance in virulence. He used advanced imaging techniques for the analysis and characterisation of three-dimensional structures during the cell division cycle in living cells. Within a joint DFG project with the ICIPE institute in Nairobi, Kenya, he performed fieldwork using high-speed microscopy in order to analyse trypanosome cell motility of natural strains isolated directly from infected animals. He joined the Trypanosome Cell Biology Unit (Philippe Bastin) at the Institut Pasteur as a post-doc in October 2015 working on the role of IFT172 in collaboration with the group of Esben Lorentzen at the Max Planck Institute in Munich, Germany. Jamin developed dSTORM to investigate IFT protein distribution at the base of the flagellum. He has moved to Munich where he now works with the microscope company Nanolive.
2019Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly, EMBO J. 2019 Apr;.
2018Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum, J. Cell Biol. 2018 Oct;217(12):4284-4297.
2016Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host, PLoS Pathog. 2016 Feb;12(2):e1005448.
2012Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei, J. Med. Chem. 2012 Mar;55(6):2538-48.