Jacques Bellalou got an Engineering degree in biochemical engineering at the University of Compiégne that was completed by a PHD. He joined the Institut Pasteur in 1980 at the laboratory of Bacterial Vaccines to work on the improvements of the whole cell and accellular vaccine against Bordetella pertussis. From 1986 to 1995 he participated, at he at the Unit of Biochemistry of Cell Regulations, to studies on the molecular mechanism of a two-component system and on the functional activity of the Bordetella adenylate cyclase. From 1996 to 1998, he worked at Unit of Cell Biochemistry and was involved in studies concerning in vitro evolution of E.coli strain adapted to thymine starvation. Since 1999, he leads a group in charge of the production and purification of recombinant proteins at the PFPR core facility. As technological co-developments with industrial partner, he developed with Fogale Nanotech Company a full-automated microfermentors device, particularly useful for difficult proteins whose production may require sophisticated processes.
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2020A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations., Sci Transl Med 2020 09; 12(559): .
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2019The Biosynthesis of Flavin Cofactors in Listeria monocytogenes, M. Sebastián, S. Arilla-Luna, J. Bellalou, et al., The Biosynthesis of Flavin Cofactors in Listeria monocytogenes, Journal of Molecular Biology.
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2018An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins, Eshghi, A, Gaultney, RA, England, P, et al. An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins. Cellular Microbiology. 2019; 21:e12949. .
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2017Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT, Sci Rep. 2017 Nov 23;7(1):16129.
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2015Binding interface between the Salmonella σ(S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl, Sci Rep 2015;5:13564.
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2015Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis, Cell 2015 May;161(4):817-32.
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2014Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase, Biochem. J. 2014 Oct;463(2):215-24.
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2013Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp, J. Bacteriol. 2013 Dec;195(24):5583-91.
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2012Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway, J. Pineal Res. 2013 Jan;54(1):46-57.
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2010Production of soluble, active acetyl serotonin methyl transferase in Leishmania tarentolae, Protein Expr. Purif. 2011 Jan;75(1):114-8.
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