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Synthesis of chemically modified nucleoside triphosphates
Marcel Hollenstein (PI)
Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]
2019On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa-Perturbed Nucleotides, ChemBioChem 2019, 20, 3032 – 3040.
2019Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers, Org. Biomol. Chem. 2019, 17, 8083 - 8087.
2019Chemical methods for the modification of RNA, Methods 2019, 161, 64-82.
2019Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids, ChemBioChem 2019, 20, 860 – 871.
2019Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide, J. Inorg. Biochem. 2019, 191, 154-163.
2018Incorporation of a minimal nucleotide into DNA, Tetrahedron Lett. 2018, 59, 4241-4244.
2017Facile immobilization of DNA using an enzymatic his-tag mimic, Chem. Commun., 2017, 53, 13031-13034.
2017On the enzymatic incorporation of an imidazole nucleotide into DNA, Org. Biomol. Chem. 2017, 15, 4449-4455.