I am working on the embodied and reciprocal nature of human cognition that encompasses biological, behavioral and social levels of organizations. I seek new conceptual and methodological approaches towards a better understanding of coordination dynamics across those scales. Methodologically, my work is at the cross-road of social psychology, cognitive neuroscience, and system biology. It uses new neuroimaging techniques such as hyperscanning (recording of multiple people’s brain activity while they are interacting) and human dynamic clamp (interaction between a human and a computational model in real-time). This allows to investigate relationships between coordination at both neural, behavioral and social levels. My main project at Human Genetics and Cognitive Function unit concerns the neurogenetics of Autism Spectrum Disorders. It aims at disentangling the strong heterogeneity at both phenotype and subphenotype levels by combining neuroimaging, system biology, and big data approaches. You can find more information on my personal website: extrospection.eu
Around 1% of children are diagnosed with autism spectrum disorders (ASD), yet there are currently no drugs designed specifically to treat their main symptoms. Working to change this is the IMI-funded EU-AIMS project. The […]
Background on the genetics of ASD
Autism spectrum disorders are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind the […]
The project SoNeTAA (Social Neuroscience for Therapeutic Approaches in Autism) combines human-human and human-machine interactions with electroencephalography (EEG) recording to approach social cognition from a situated and reciprocal standpoint. The project especially focuses on […]
Recent progress in sequencing and bioinformatics methods have given access to ancient DNA. This project aims at understanding the differential evolutionary pressure on the key proteins implicated in the nervous system, especially those related […]
Phelan McDermid Syndrome: from mechanisms to treatments
Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with non-specific clinical features. The main symptoms are hypotonia, intellectual disability (ID), absent or delayed speech together with minor dysmorphic features. More than half of the patients […]
Imaginons la recherche
“Imaginons la recherche” is a project for supporting structural change in research organisations to promote Responsible Research and Innovation (RRI) as defined by the european commission : Public engagement (outreach & citizen science) Gender […]
The serotonin-NAS-melatonin pathway and susceptibility to ASD
Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]
Brain imaging and genetics
Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]
Gravity (for Gene inteRaction Analysis of Variants in Individuals: a Tool for You) provides a visualisation of genetic data from SNP array, whole genome and whole exome data in the context of protein-protein interactions. […]
2018Differential brain-to-brain entrainment while speaking and listening in native and foreign languages, Cortex 2018 Dec;.
2018Experimenting with Reproducibility: a case study of Robustness in Bioinformatics, Gigascience 2018 Jun;.
2018Brain-to-brain coupling during handholding is associated with pain reduction, PNAS 2018 Feb; 0027-8424.
2017A roadmap to computational social neuroscience, Cogn Neurodyn 2018 Feb;12(1):135-140.
2017The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders, Mol Autism 2017;8:24.
2017The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation, Mol Autism 2017;8:27.
2017From clinic to the “foul and exciting field of life”: A psychiatric point of view on clinical physiology, Annales Médico-Psychologiques, Revue Psychiatrique. 2017 Jan;175(1).
2016Enhanced emotional responses during social coordination with a virtual partner, Int J Psychophysiol 2016 Jun;104:33-43.
2016The Regulation of Task Performance: A Trans-Disciplinary Review, Front Psychol 2015;6:1862.
2015The Virtual Teacher (VT) Paradigm: Learning New Patterns of Interpersonal Coordination Using the Human Dynamic Clamp, PLoS ONE 2015;10(11):e0142029.
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