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Understanding viral attenuation for the rationalization of vaccine design
Nolwenn Jouvenet (PI)
Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence […]
2019LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses, Sci Signal 2019 Oct;12(601).
2019Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti, PLoS Negl Trop Dis 2019 08;13(8):e0007299.
2019Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen, Viruses 2019 01;11(1).
2018DI-tector: defective interfering viral genomes’ detector for next-generation sequencing data, RNA 2018 10;24(10):1285-1296.
2018RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes., Cell Rep. 2018 Jul 10;24(2):320-328.