Expansion of the genetic alphabet with metal base pairs
Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
Therapeutic tools based on nucleic acids
An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
2021Recent progress in non-native nucleic acid modifications, Chem. Soc. Rev. 2021, 50, 5126–5164.
2020Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer, Chem. Sci., 2020, 11, 2657-2663.
2019Chemical methods for the modification of RNA, Methods 2019, 161, 64-82.