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About

Our research focuses on mechanisms underlying the epigenetic regulation of alternative RNA splicing. In particular, we are interested in deciphering the cross-talks between the chromatin organization, and both transcriptional and spliceosome machineries which involve several chromatin-remodeling factors, splicing factors, the RNA-polymerase II (RNAPII), and also non-coding RNA molecules.

Our works have contributed to discover a new function of RNA silencing pathways in mammals. We found that nuclear Argonaute proteins bound to small RNAs are involved in the modulation of mRNA alternative splicing decision by affecting RNAPII elongation through chromatin remodeling.

Our goal is to understand how non-coding RNAs and in particular cryptic long intragenic RNAs are regulated through chromatin/epigenetic modifications and can participate to the regulation of one of the main process which generate protein diversity (alternative splicing). We are notably focusing
– on the role of antisense non-coding RNA in the alternative splicing decision.
– on the regulation of cryptic intragenic transcription through the epigenetic control.
– on their disregulation and their influence during the tumoral progression.

 

Projects

CV

Degrees and experiences

  • Predoctoral trainee on malaria and vaccines, at Institut Pasteur (1990 & 1991)
  • Master in Biology & Biochemistry, Université Pierre et Marie Curie (Paris VI), 1992
  • Predoctoral trainee on immune system and corticotroph axis, as scientist of the army, INRA Jouy-en-Josas, 1993
  • PhD of Molecular & Cellular Biology, (Oncogenes and epithelial cells), Université Paris VI, 1999
  • Postdoctoral fellowship on tumor suppressor genes and corticotroph transcription, Molecular Genetic Laboratory, Institut de Recherche de Montreal (IRCM), Canada (1999-2003)
  • Postdoctoral fellowship on chromatin remodeling and RNA processing in the M Yaniv lab, Institut Pasteur (2003-2006)
  • Scientist, french National Center of Scientific Research (CNRS), 2006
  • Accreditation to supervise research (HDR) Université Diderot (Paris VII), 2014

Supervisor of PhD students

  • Jia Yi, PhD in the Pasteur-Paris University International doctoral program (2016-ongoing)
  • Nowsheen Mullani, PhD, Université Paris VI (2015-ongoing)
  • Oriane Mauger, Master & PhD, Université Paris VI (2010-2014)
  • Violaine Saint-André,  PhD, Université Paris VI (2006-2010)

Other sudents supervised during their predoctoral trainee

  • Natalie Jones (Jan-Jun 2016), visiting PhD student from McGill University (Canada)
  • Leslie Landemaine (Jan-Avr 2016), M1 Univ. Paris VI
  • Leslie Lepont (Jun-Jul 2015), L2 Univ. Paris VI
  • Charlotte Hamner-Lloyd (Oct 2014 – Jul 2015), ERASMUS from Keele University (UK)
  • Jessy Marie-Sainte (Jun-Jul 2014), L2 Univ. Creteil
  • Ben Hopkins (Sept 2013 – Jun 2014), ERASMUS from Keele University (UK)
  • Asma Hentati (Juil-Aug 2013), Master1 Univ. Clermont-Ferrand

Publications

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