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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.

About

Dr Darragh P. O’Brien has over a decade of experience as a protein biochemist in both academic and industrial environments, and his portfolio includes a wide array of mass spectrometry (MS) and proteomic techniques. He currently works as a senior post-doctoral researcher at Institut Pasteur in Paris, France, under the supervision of Dr. Alexandre Chenal, where he utilises biophysical and MS-based approaches for the structural analysis of the adenylate cyclase toxin. Prior to this, Dr O’Brien undertook post-doctoral training in the group of Dr. John Timms at University College London, United Kingdom. The primary focus of his research was the discovery and verification of biomarkers of preclinical pancreatic cancer in serum using MS and immunoassays for protein characterisation and quantitation. In 2011, he completed a PhD in Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, under the supervision of Professor Sir Simon Lovestone. Here, he utilised selected reaction monitoring MS in combination with isobaric protein tagging for the development and implementation of a novel, multiplexed assay for the validation of candidate plasma and cerebrospinal fluid biomarkers of Alzheimer’s disease in large, longitudinal cohorts of disease and control samples. Dr O’Brien’s PhD followed an Honours Degree in Biochemistry at University College Dublin, Ireland, where his final year project investigated proteolytic degradation patterns of amyloid-beta protein in Alzheimer-like diseases, under the direction of Professor Dominic Walsh.

 

Projects

CV

  • 2013 – Present: Post-doctoral Researcher at Institut Pasteur, Paris, France
  • 2011 – 2013: Post-doctoral Researcher at University College London, UK
  • 2007 –  2011: Ph.D, Neuroscience at King’s College London, UK                    
  • 2005 –  2011: Research Assistant in Mass Spectrometry and Proteomics at Proteome Sciences Plc, London, UK  
  • 2000 –  2004: BSc (Hons), Biochemistry at University College Dublin, Ireland         

Publications

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