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Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Sylvie Pochet (PI)
Nucleoside analogues as potential antitumor agents. This project aims to characterize and validate the nucleotide N-hydrolase DNPH1 as a new target in oncology. Inhibition of Rcl alone or in combination with other chemotherapeutic drugs […]
2015Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides, Tetrahedron, 71, 2525-2529..
20146-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
2013N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1, PLoS ONE 2013;8(11):e80755.
2013Structure of the oncoprotein Rcl bound to three nucleotide analogues, Acta Crystallogr. D Biol. Crystallogr. 2013 Feb;69(Pt 2):247-55.