Dr. Muchardt is Director of Research, class 1, at the CNRS. His laboratory at the Institut Pasteur is studying the role of epigenetic in the onset of diseases, with a special interest for cancer and multiple sclerosis.
Important contributions have focused on the role of chromatin remodeling machineries in cellular transformation. More recently, the lab has provided pioneering data on the impact of chromatin on the regulation of alternative splicing in mammalian cells, with an unexpect contribution on the RNAi machinery and non-coding RNAs. The lab has also shown that, in patients with multiple sclerosis, some of the symptoms can be correlated with defects in the chromatin-dependent silencing machineries.
Dr Muchardt was associated with the Epigenome Network of Excellence (2005-2009). Presently, he is of member of the LABEX network “Revive” dedicated to the study of stem cells and regenerative medicine. He is also associated with the European FP7 EpigeneSys network on epigenetics in systems biology. In 2005, he was a laureate of the INSERM Avenir program and he was awarded the “Price of Excellence “ from the France-Israel Foundation in 2008. In 2011, he received the bonus for scientific excellence from the CNRS. Dr. Muchardt’s laboratory is funded by a core funding from the Institut Pasteur and CNRS, and by grants from the ANR, the FRM , the ARSEP, and the LABEX Revive.