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About

Dr. Muchardt is Director of Research, class 1, at the CNRS. His laboratory at the Institut Pasteur is studying the role of epigenetic  in the onset of diseases, with a special interest for cancer and multiple sclerosis.

Important contributions have focused on the  role of chromatin remodeling machineries in cellular transformation. More recently, the lab has provided pioneering data on the impact of chromatin on the regulation of alternative splicing in mammalian cells, with an unexpect contribution on the RNAi machinery and non-coding RNAs. The lab has also shown that, in patients with multiple sclerosis, some of the symptoms can be correlated with defects in the chromatin-dependent silencing machineries.

Dr Muchardt was associated with the Epigenome Network of Excellence (2005-2009). Presently, he is of member of the LABEX network “Revive” dedicated to the study of stem cells and regenerative medicine. He is also associated with the European FP7 EpigeneSys network on epigenetics in systems biology. In 2005, he was a laureate of the INSERM Avenir program and he was awarded the “Price of Excellence “ from the France-Israel Foundation in 2008. In 2011, he received the bonus for scientific excellence from the CNRS. Dr. Muchardt’s laboratory is funded by a core funding from the Institut Pasteur and CNRS, and by grants from the ANR, the FRM , the ARSEP, and the LABEX Revive.

Projects

CV

(FR)

BORN :                                                  August 1965 Copenhagen – Denmark

EDUCATION :

  • 2003: Habilitation (HDR) Paris University 7
  • 1992-1993: Postdoctoral Fellow at the Institut Pasteur – Paris. Research Topic: Characterization of a human SWI/SNF complex. Advisor: Prof. Moshe Yaniv.
  • 1992: PhD in Microbiology-Biotechnology, INSA Toulouse. Thesis: Transcriptional regulation of the human retroviruses HIV-1 and HTLV-1. Research studies were done in the laboratory of Dr Richard Gaynor at UCLA.

LABORATORIES :

  • 2006-present: Head Unit. « Epigenetic Regulation » at the Institut Pasteur. Unit rated “outstanding” by the HCERES evaluation committee in February 2015.
  • 1999-2006: Group leader. « Chromatin, transcription, and diseases ». CNRS unit headed by Moshe Yaniv at the Institut Pasteur.
  • 1996-1999: Group leader. « Remodeling of chromatin during transcription ». CNRS unit headed by Moshe Yaniv at the Institut Pasteur.

Honors:

  • Prix d’excellence académique Franco-Israélien 2008
  • Lauréat AVENIR INSERM 2005

Advisory commitees

  • 2010-2013: Elected member of the Scientific Evaluation Committee (COMESP) at the Institut Pasteur.
  • 2006-2011: Membre de la commission d’expertise régionale « Ile de France » (CR1) de l’ARC.
  • 2005-2009: Membre du conseil scientifique national de la LIGUE CONTRE LE CANCER, Président de la commission d’expertise « génétique et oncogenèse » (section 1).
  • 1998-2004: Membre nommé du Comité National de la Recherche Scientifique (Section 23)

EDITORIAL ACTIVITIES

Member of the editorial board of “Epigenomics”

RESEARCH ADMINISTRATION

2012-present: Deputy Director of the Departement of Developmental and Stem Cell Biology

2006-2009: Président du Comité de Site “Fernbach-Animalerie” à l’Institut Pasteur.

NETWORKS

  • Member of the LabEx ‘REVIVE’ (Stem cells)
  • Member of the STEM-pôle (Ile-de-France)
  • Associated with the Epigenesys Network of Excellence

Publications

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