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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
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Structured Illumination Microscopy image of a migrating glioma cell showing the actin filaments (cyan), microtubules (yellow) and the intermediate filaments (magenta)
Structured Illumination Microscopy image of a migrating glioma cell showing the actin filaments (cyan), microtubules (yellow) and the intermediate filaments (magenta)

Using a combination of cutting edge microscopy techniques, I am investigating the physical mechanisms responsible for intermediate filaments dynamics in migrating cells and how they are controlled.

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