Protein synthesis machinery of Trypanosomatid as a therapeutic target
Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
A synthetic glycopeptide for anti-tumor immunotherapy: from design to first use in human
Within the framework of developing a carbohydrate-based vaccine against cancer, we designed and prepared the MAG-Tn3, a fully synthetic immunogen based on the tumor-associated Tn antigen. The MAG-Tn3 is a glycopeptide associating Tn clusters […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987
Detailed information on drug-target interaction is a prerequisite in academic and industrial programs of drug dicovery and hit-to-lead optimization. We present a new approach that combines NMR and docking to characterise drug-target interactions at […]
2018Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR., Biochemistry. 2019 Feb 12;58(6):526-533. doi: 10.1021/acs.biochem.8b00975. .
2016Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate, Org. Biomol. Chem. 2016 Dec;15(1):114-123.
2016Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach., Biochem J. 2016 May 13. pii: BCJ20160131.
2014Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR, PLoS ONE 2014;9(4):e89502.
2014Chemical organization of the cell wall polysaccharide core of Malassezia restricta, J. Biol. Chem. 2014 May;289(18):12647-56.
2013The structure of HasB reveals a new class of TonB protein fold, PLoS ONE 2013;8(3):e58964.
2012Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN, Sci Signal 2012 Aug;5(237):ra58.
2012(1)H, (13)C and (15)N resonance assignments of the periplasmic signalling domain of HasR, a TonB-dependent outer membrane heme transporter, Biomol NMR Assign 2013 Apr;7(1):43-6.
2011Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus, PLoS Pathog. 2011 Nov;7(11):e1002372.
2011Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance, Glycobiology 2011 Dec;21(12):1570-9.
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