Caroline Proux is holding a DESS in “Ressources génomiques et traitements informatiques”. She firstly worked at the INRA and joined the platform in 2009 where, as engineer, she was involved in transcriptomics projects based on DNA microarray technology. Since 2010, she is in charge of many projects aiming at gene expression profiling by Next Generation Sequencing (RNAseq, ChIPseq) from the quality control of the samples to the generation of the sequencing data. She is also deeply involved in user training and technological survey activities.
Training: analysis of the transcriptome by RNAseq
The Transcriptome and Epigenome platform of the Biomics pole is organizing a one week (October 10, 2016 – October 14, 2016) training session dedicated to the analysis of the transcriptome by RNAseq. It is […]
Transcriptome of different quiescence sub-states of neural stem cells in adult zebrafish
Vertebrate adult neural stem cells (NSCs) are generally quiescent, and the frequency of their cell cycle re-entry (“activation”) conditions their lifespan. Little is known of the molecular pathways controlling the NSC quiescence/activation balance. We […]
Interactions between HP1 proteins and RNA
The three HP1 proteins (Heterochromatin Protein 1 alpha, -beta, -gamma) are epigenetic markers of heterochromatin, the condensed, repressed form of chromatin. They are typically known to associate to the di-/tri-methylated lysine 9 of histone […]
Gene expression profiling in germinal center B cells
Germinal centers (GC) are essential for an effective humoral immune response. The GC provides an environment that stimulates B cells to proliferate in response to antigens and accumulate somatic mutations in immunoglobulin (Ig) genes, […]
S. cerevisiae gene regulation in quiescence
In wild life, yeast cells are able to survive in severe conditions, without nutriment for a long period of time because the cell is able to enter in stationary phase. During this phase, the […]
The platform also has important technological and bibliographical survey activities for the wet lab as well as for the dry lab. Over the last months, the platform has established methods for the transcriptome sequencing […]
Régulation transcriptionnelle par l’Enhancer de Trithorax et Polycomb Corto et la Protéine Ribosomique L12.
Il est aujourd’hui connu que les protéines ribosomiques ont des fonctions extra-ribosomiques, et qu’en particulier, certaines d’entre elles contrôlent la transcription. Nous avons montré que, chez la drosophile, RPL12 interagit avec le facteur épigénétique […]
2017In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells, Cell Reports , Volume 21 , Issue 7 , 1982 - 1993.
2017Comparison of biofilm formation and motility processes in arsenic-resistant Thiomonas spp. strains revealed divergent response to arsenite, Microb Biotechnol. 2017 Feb 7. doi: 10.1111/1751-7915.12556.
2016Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network, Nat. Cell Biol. 2016 Oct;.
2016Intron retention-dependent gene regulation in Cryptococcus neoformans, Sci Rep 2016 Aug;6:32252.
2015Normal and Cystic Fibrosis Human Bronchial Epithelial Cells Infected with Pseudomonas aeruginosa Exhibit Distinct Gene Activation Patterns, PLoS ONE 2015;10(10):e0140979.
2015Adaptation in Toxic Environments: Arsenic Genomic Islands in the Bacterial Genus Thiomonas, PLoS ONE 2015;10(9):e0139011.
2014DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression, EMBO Rep. 2014 Jun;15(6):686-94.
2014Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation, PLoS Genet. 2014 Apr;10(4):e1004261.
2014Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism, BMC Microbiol. 2014;14:81.
2014The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing, Mol. Cell 2014 Jan;53(2):277-89.
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