Click to view graph
Click to view timeline
Natural Control of HIV-1 Infection
Asier Sáez-Cirión (PI)
HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]
2017p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity, J. Virol. 2017 Dec;91(23).
2017Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents, J. Virol. 2017 03;91(6).
2016Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers, J. Immunol. 2016 Aug;.
2016Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles, PLoS ONE 2016;11(8):e0160251.
2016Long-term Spontaneous control of HIV-1 relates to low frequency of infected cells and inefficient viral reactivation, J. Virol. 2016 Apr; 90(13):6148-58.
2015HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report, Lancet HIV 2016 Jan;3(1):e49-54.
2014Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block, Proc. Natl. Acad. Sci. U.S.A. 2014 Apr;111(14):E1325-6.
2013p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway, Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(42):E3997-4006.
2011Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers, Blood 2011 Jul;118(4):955-64.
2009The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages, J. Virol. 2009 Dec;83(23):12253-65.
+View full list of publications