Inhibition of peptidoglycan assembly complexes
The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]
The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. […]
Biology and Genetics of Bacterial Cell Wall
Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]
2017N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes, Nat Microbiol 2017 Feb;2:17005.
2014Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members, Acta Crystallogr. D Biol. Crystallogr. 2014 Oct;70(Pt 10):2631-9.
2013De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis, Mol. Microbiol. 2013 Mar;87(5):1100-12.
2012The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori, Microb. Drug Resist. 2012 Jun;18(3):230-9.