Aleks Nivina is a PhD student at the Bacterial Genome Plasticity Unit at Institut Pasteur, directed by Prof.Didier Mazel. She is developing the synthetic integron, a novel DNA recombination system. In order to engineer such a system, she studies cassette recombination sites (attC) of the integron.
Aleks obtained her Masters degree in Synthetic and Systems Biology at the Center for Research and Interdisciplinarity (CRI) in Paris and is now enrolled in the interdisciplinary PhD program “Frontiers of Life Sciences”. She also holds a Doctoral degree in Pharmacy, from the Paris Descartes University.
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2017Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation, Biotechnology & Bioengineering (2018) 115(1):184-191. doi: 10.1002/bit.26450 .
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2017Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality, Nucleic Acids Research (2017) 45(18):10555-10563. doi: 10.1093/nar/gkx670 .
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2017Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance, MBio 2017 Mar;8(2).
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2016Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites., Nucleic Acids Res. 2016 Aug 5. pii: gkw646. [Epub ahead of print].
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2016Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation., Nat Commun. 2016 Mar 10;7:10937. doi: 10.1038/ncomms10937..