Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.

About

 

My focus is on the basic molecular mechanisms involved in neuronal signaling. Specifically I study the pentameric ligand-gated ion channel (pLGIC) family of receptors and the relationship between their structure and function. My current projects revolve around the nicotinic acetylcholine receptor (nAChR) subfamily with specific focus on the alpha5 accessory subunit.

I completed my doctoral thesis at the University of California-San Diego under the supervision of Dr. Palmer Taylor who at the time was the dean of the school of Pharmacy. Although I obtained my degree through the department of Biochemistry and Chemistry with the co-supervision of Dr. Elizabeth Komives, my training spanned the themes of pharmacology, neuroscience, and biochemistry. In an effort to study the specificities of ligand binding and subsequent therapeutic development against neuro-degenerative diseases, I created a humanized template of the alpha7-nAChR extracellular domain during my doctoral work. This X-ray crystallographically resolved template was used in an in situ click-chemistry approach to fragment based drug design against the alpha7-nAChR receptor. Additionally in conjunction with Dr. John Yamauchi we adapted a previously developed G-protein muscarinic acetylcholine receptor cell-based neurotransmitter fluorescent engineered reporter (CNiFER) to the pLGIC family.

In my post-doctoral fellowship with Dr. Pierre-Jean Corringer in the department of Neuroscience my focus shifted to primarily a structural biological approach. I worked with glycine receptors, nAChRs, and prokaryotic pLGICs to study the mechanisms of activation. My specific works included: using an electrophysiological approach I studied the mechanism of proton-activation of the Gloeobacter violaceus ligand-gated ion channel (GLIC), studying lipid binding to the GLIC and a GLIC/glycine receptor chimera, and attempting to incorporate a glycine binding site in the GLIC. In collaboration with Dr. Pierre Lafaye and the laboratories of Pierre Fabre we created VHH nanobodies against specific nAChR extracellular domain sites. Finally in collaboration with Dr. Marc Delarue, I functionally described a new proteobacterial pLGIC found in an endosymbiont of Tevnia jerichonana, termed sTeLIC, which was structurally resolved by Dr. Haidai Hu.

 

Publications

Download