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Scientific Fields
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News
News

‘ILC-poiesis’: A new model of human ILC differentiation

19
Mar 2017
Innate Immunity
Immunology
Center for Translational Science
Ai Ing Lim
Yan Li
Silvia Lopez Lastra
Armanda Casrouge
Nicolas Serafini
Laura Surace
Guillemette Masse-Ranson
Hélène Strick-Marchand
Lars Rogge
James Di Santo

Ai Ing’s paper on human ILC precursors was recently published in Cell.  Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017 Mar 9;168(6):1086-1100.e10. doi: 10.1016/j.cell.2017.02.021. Ai Ing Lim,1,2,3 Yan Li,1,2 […]

Projects

project
Ongoing
5 Members

Deciphering Human Innate Lymphoid Cell Biology

James Di Santo (PI)

ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs […]
project
Ongoing
7 Members

ERC-2015-AdG ILC_REACTIVITY

James Di Santo (PI)

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
project
Ongoing
8 Members

Mouse Model to Understand Innate Lymphoid Cell Biology

James Di Santo (PI)

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]