With the worldwide emergence of antimicrobial resistance (AMR) innovative therapeutic strategies are needed. Drugs targeting bacterial virulence factors constitute an attractive strategy with a lower likelihood of emergence of resistance. Using genetic and functional approaches the team has identified inhibitors of enzymes involved in the biogenesis and function of a virulence factor found in numerous bacterial pathogens. The main goal of the proposed project is to optimize lead compounds in collaboration with organic/medicinal chemists. Compound efficiencies will be evaluated in vitro on enzyme activity assays, on bacteria alone or in interaction with host cells.
We are looking for a highly motivated young investigator with the will to develop innovative antimicrobial treatment strategies. Knowledge in biochemistry, structural biology, cell biology and microbiology are expected. Practical training in biochemistry, enzymology, structural biology and pharmacology is needed.
Informal inquiries are welcome and should be directed to Dr Guillaume Dumenil at email@example.com. To apply please submit by email a letter of interest, curriculum vitae and names of two references to Dr Guillaume Dumenil, INSERM U1225, Institut Pasteur Paris, 28 rue du Dr Roux, 75015 Paris, France.