An ERC-funded postdoctoral position is available in the lab “Stroma, Inflammation and Tissue Repair” to study the regulation of immune responses and tissue repair by stromal cells.
Our lab investigates the role of stromal mesenchymal cells in tissue injury/repair and in experimental models of inflammation and cancer. We have previously shown that stromal cells are essential to organize inflammation (JI 2009) and identified specific mesenchymal perivascular progenitors with a central role in skeletal muscle and skin scarring (Nature Medicine 2012). Recently, we characterized the mesenchymal niche for intestinal epithelial stem cells (PNAS 2017). Using mice models developed in the lab, the aim of this project is to define the function of specific subsets of mesenchymal cells in inflammatory/fibrotic diseases (with a focus on skin, pulmonary or intestinal diseases), and identify the underlying molecular mechanisms. In this context, we will more specifically investigate the stromal crosstalk with immune cells, tissue stem cells and the vascular niche.
The study will involve wide range of techniques including in vivo lineage tracing/ genetic depletion approaches, experimentals models for tissue injury/inflammation, cell imaging, flow cytometry and transcriptomic studies. This project provides opportunities for interdisciplinary training, as it is at the crossroads of immunology, vascular biology and the emerging field of stromal biology.
This position is part of a recently awarded ERC project aiming at identifying new therapeutic approaches in inflammatory diseases, regenerative medicine and cancer. For more information about our laboratory, please visit our website: http://www.pasteur.fr/research/stromalcells.
The successful candidates will have a PhD or MD/PhD, and a proven track record of achievement in immunology or vascular/stromal biology. Previous experience with multi-parametric flow cytometry and cell sorting will be appreciated. Highly motivated candidates with creative and innovative skills are especially encouraged to apply. The Institut Pasteur in Paris offers an international, dynamic and stimulating scientific campus with more than 1500 researchers working in 11 Departments favouring multiple collaborations, and access to top-notch plateforms.
To apply, please send your complete CV, motivation letter and contact information for 3 references, to: firstname.lastname@example.org.