An ERC-funded postdoctoral position is available in the lab “Stroma, Inflammation and Tissue Repair” to study the regulation of immune responses and tissue repair by the stromal microenvironment.
The stromal microenvironment is emerging as a novel and essential player in a number of human diseases characterized by overactivation or suppression of the immune system, including chronic inflammatory diseases, autoimmune diseases, and cancer. However the underlying mechanism(s) remain unclear. Taking advantage of new experimental tools generated in the lab, the aim of this project is to define the role of recently identified stromal mesenchymal subsets in inflammatory/fibrotic diseases (with a focus on skin, pulmonary or intestinal diseases), characterize the cellular and molecular crosstalk with immune cells and the vascular niche, and determine their impact on the immune response and disease pathogenesis.
The study will involve wide range of techniques including in vivo lineage tracing/ genetic depletion approaches, experimentals mouse models for tissue injury/inflammation, cell imaging, flow cytometry and transcriptomic studies. This project provides opportunities for interdisciplinary training, as it is at the crossroads of immunology, vascular biology and the emerging field of stromal biology.
This position is part of a recently awarded ERC project aiming at identifying new therapeutic approaches in inflammatory diseases, regenerative medicine and cancer. For more information about our laboratory, please visit our website: http://www.pasteur.fr/research/stromalcells.
The successful candidate will have a PhD or MD/PhD, and a proven track record of achievement in immunology or vascular/stromal biology. Previous experience with multi-parametric flow cytometry and cell sorting will be appreciated. Highly motivated candidates with creative and innovative skills are especially encouraged to apply. The Institut Pasteur in Paris offers an international, dynamic and stimulating scientific campus with more than 1500 researchers working in 11 Departments favouring multiple collaborations, and access to top-notch plateforms.
To apply, please send your complete CV, motivation letter and contact information for 3 references, to: firstname.lastname@example.org.