Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.
Scientific Fields
Diseases
Organisms
Applications
Technique
Application Deadline
30
Apr 2020
2020-04-30 8:00:00 2020-04-30 18:00:00 Europe/Paris Postdoctoral position in microbiology Ionome and metabolic remodeling in the persistence and wake up of quiescent Salmonella A post-doctoral position is available under the supervision of Dr. Françoise Norel in the lab “Biochemistry of Macromolecular Interactions, CNRS UMR3528” […] "25-28 rue du Dr. Roux, 75015, Paris" Françoise Norel-Bozouklian francoise.norel@pasteur.fr

Ionome and metabolic remodeling in the persistence and wake up of quiescent Salmonella

A post-doctoral position is available under the supervision of Dr. Françoise Norel in the lab “Biochemistry of Macromolecular Interactions, CNRS UMR3528” at the Institut Pasteur, to study the remodeling of metabolism and ionome of quiescent Salmonella by the stress sigma factor SigmaS.

Overview

The entry into a non-actively growing/quiescent state is a common strategy used by bacteria to survive under stressful conditions, including antibiotic treatment. Our group aims at understanding key molecular and physiological determinants that orchestrate survival during this temporary arrest of proliferation and revival when conditions again become favorable. In the wide host-range foodborne pathogen Salmonella enterica serovar Typhimurium and other Gram-negative bacteria, this arrest of proliferation induces the expression of the alternative sigma subunit of RNA polymerase, SigmaS, which remodels global gene expression to reshape the cell physiology and ensure survival under starvation and various stress conditions. Our integrated transcriptomics, proteomics and physiological analyses of the SigmaS response in S. Typhimurium have revealed extensive reprogramming of membrane and metabolic functions that might confer fitness advantages to quiescent cells and/or populations.

https://research.pasteur.fr/en/team/group-francoise-norel-bozouklian/

Project

The project will focus on two important but poorly understood (metabolism) or unexplored (ion homeostasis) aspects of bacterial quiescence, using analytical approaches (physiology, biochemistry) and quantitative global analyses (proteome, metabolome). We expect this project to reveal key physiological and metabolic features driving the persistence and ability to wake up of quiescent cells. Relevant collaborations are in place.

Application details

The position is financed by the ANR (The French national research granting agency) for 30 months and is expected to start in July 2020 (flexible).

Highly motivated candidates should have a PhD in the biological sciences and strong background in molecular microbiology. Prior experience in fluorescence microscopy/cell imaging and molecular biology is highly desirable. Experience in flow cytometry, bioinformatics and statistics will be positively evaluated. The candidate should have less than two years experience after his/her Ph.D.

Applicants should send a cover letter with a brief statement of research experience, technical expertise and interests, a detailed CV and contact information of three referees to Françoise Norel (francoise.norel@pasteur.fr)