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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Job

Post-doctoral position: Deciphering Legionella pneumophila induced epigenetic modifications

Scientific Fields
Diseases
Organisms
Applications
Technique
Application Deadline
31
Jan 2019
2019-01-31 8:00:00 2019-01-31 18:00:00 Europe/Paris Post-doctoral position: Deciphering Legionella pneumophila induced epigenetic modifications Project: Our main research question is to understand how L. pneumophila subverts host functions to replicate in the host cell and to cause disease. A specific question in this context is how does L. […] "25-28 rue du Dr. Roux, 75015, Paris" Monica Rolando monica.rolando@pasteur.fr

Project:
Our main research question is to understand how L. pneumophila subverts host functions to replicate in the host cell and to cause disease. A specific question in this context is how does L. pneumophila target the host cell nucleus to change the cellular response.
We have described an effector (RomA) that marks histones to down regulate the host response during infection (Rolando, M. et al. Cell Host Microbe 13, 395–405 (2013)).
Recently, our in-depth search for additional putative chromatin modifying effectors led to the identification of five such proteins.
The successful candidate will be involved in the characterization of the chromatin signature of L. pneumophila during infection by analyzing the activities of the secreted nucleomodulines

Requirements:
The ideal candidate would have experience in cell biology, biochemistry and chromatin analyses.
Excellent written and oral communication skills and proficiency in English are required. French is optional.
The candidate should have good interpersonal skills and ability to work independently, but also to interact well within a research group.
The candidate is expected independently establish all necessary techniques and introduce new technologies.

The work will be performed under the supervision of Dr. Monica Rolando.

Application:
Please send to mrolando@pasteur.fr and cbuch@pasteur.fr a cover letter, a full CV and contact informations for three references.

The position will last for three years and will start the latest in April 2019.