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© Antoinette Ryter
Serratia marcescens avec présence de flagelles (cils) péritriches. Famille des Enterobacteriaceae, bacille à Gram négatif, non sporulé, anaérobie facultatif, mobile, parfois encapsulé, pouvant synthétiser un pigment rouge ou rose. Présent dans les végétaux , le sol, et l'eau. A l'origine d'infections nosocomiales et résistant à de nombreux antibiotiques. Image colorisée.
Scientific Fields
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Application Deadline
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Jan 2019
2019-01-15 8:00:00 2019-01-15 18:00:00 Europe/Paris Post-doctoral position: CRISPR biology and technologies in bacteria The Bikard lab at Institut Pasteur in Paris is seeking to hire a postdoctoral researcher to work on CRISPR-Cas systems and their application to study and fight pathogenic bacteria. Technologies derived from CRISPR-Cas systems […] "25-28 rue du Dr. Roux, 75015, Paris" David Bikard david.bikard@pasteur.fr

The Bikard lab at Institut Pasteur in Paris is seeking to hire a postdoctoral researcher to work on CRISPR-Cas systems and their application to study and fight pathogenic bacteria. Technologies derived from CRISPR-Cas systems offer tremendous potential to modify bacterial genomes, control gene expression or specifically kill virulent bacteria. Here are some of our focus of interest:

  • We are deciphering the properties of Cas proteins in bacteria and their interaction with DNA repair pathways, providing insights into the mechanism and evolution of CRISPR-Cas systems as bacteriophage defense systems (Bernheim et al, 2017)
  • We are refining CRISPR-Cas tools for bacteria and building powerful design tools using machine learning approaches (Soriano et al, 2018; Cui et al, 2018; Vigouroux et al, 2018)
  • We are developing CRISPR screens as powerful tools to investigate gene function and decipher genetic interaction networks (Rousset et al, 2018)
  • We are engineering bacteriophages to use them as DNA delivery vectors, with applications to the development of sequence-specific antimicrobials (Bikard et al, 2014; Bikard & Barrangou, 2017)

The successful candidate will be able to define his own line of research within the scope of interest of the lab with the support of David and other lab members.

The expected start date is in the Spring 2019. The position is initially for one year, with the possibility of extension. Salary is commensurate with experience according to the Institut Pasteur guidelines.

Required skills:

  • General microbiology and molecular biology techniques

Recommended skills:

  • Genomics techniques (DNA sequencing, RNA-seq, Chip-seq etc.)
  • Data analysis and statistics (R, Python)

Qualified applicants should send their CV, a statement of research interests and the contact information of two referees to david.bikard@pasteur.fr

 

Bernheim A, Calvo-Villamañán A, Basier C, Cui L, Rocha EPC, Touchon M & Bikard D (2017) Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria. Nat. Commun. 8: 2094

Bikard D & Barrangou R (2017) Using CRISPR-Cas systems as antimicrobials. Curr. Opin. Microbiol. 37: 155–160

Bikard D, Euler CW, Jiang W, Nussenzweig PM, Goldberg GW, Duportet X, Fischetti VA & Marraffini LA (2014) Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol 32: 1146–50

Cui L, Vigouroux A, Rousset F, Varet H, Khanna V & Bikard D (2018) A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9. Nat. Commun. 9: 1912

Rousset F, Cui L, Siouve E, Becavin C, Depardieu F & Bikard D (2018) Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors. PLOS Genet. 14: e1007749

Soriano BG, Ng JW, Cui L, Becavin C & Bikard D (2018) Genome-wide CRISPR-Cas9 screen in E. coli identifies design rules for efficient targeting. bioRxiv: 308148

Vigouroux A, Oldewurtel E, Cui L, Bikard D & Teeffelen S van (2018) Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes. Mol. Syst. Biol. 14: e7899