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Scientific Fields
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Application Deadline
15
Oct 2018
2018-10-15 8:00:00 2018-10-15 18:00:00 Europe/Paris POST-DOCTORAL POSITION – Challenging DNA and histone methylation POST-DOCTORAL POSITION at Institut Pasteur in Paris, France Challenging DNA and histone methylation We are looking for a talented and curiosity-driven post-doc interested at the interface of chemistry and biology to join us at […] "25-28 rue du Dr. Roux, 75015, Paris" Paola Arimondo paola.arimondo@pasteur.fr

POST-DOCTORAL POSITION at Institut Pasteur in Paris, France

Challenging DNA and histone methylation

We are looking for a talented and curiosity-driven post-doc interested at the interface
of chemistry and biology to join us at the Institut Pasteur. Epigenetic modifications act
together with transcription factors and other proteins to establish the expression profiles that
are inherited from cell to cell, integrating various environmental stimuli. In cancers,
alterations of the epigenetic landscape have been observed, but also in other pathologies.
We have developed and characterized in cancer cells inhibitors of DNA methylation (reviews:
Pechalrieu et al. Biochem Pharmacol. 2017;129:1-13; Lopez et al. Adv Exp Med Biol. 2016; 945:431-
473; Erdmann et al. J Med Chem. 2015 58(6):2569-83), and have recently started to apply with
success our approaches to histone methylation (Castillo-Aguilera et al. Biomolecules. 2017; 7(1).
pii: E3; Halby et al. Phil. Trans RS B, 2018, 373(1748)). The Epigenetic Chemical Biology Unit is
composed of chemists and biologists working together in synergy.
The successful candidate will be in charge of the biological evaluation of an oriented
chemical library targeting DNA and histone methylation designed and synthetized in house.
She/he will manage three aspects of the project:
-the development of robust assays, in vitro and/or in cells, to screen the oriented
chemical library.
-the biological validation of the hits by enzymatic, biophysical assays and
phenotypical characterization.
-the optimization of the hit together with the chemists to propose a potential drug
candidate or a chemical probe.
The candidate should have skills in enzymology, biochemistry, molecular and cellular
biology, and microscopy. A crosstalk with the chemists of the team is essential to the project.
In addition, the screening will be developed in collaboration with other teams of the Institut
Pasteur, thus he/she should be very open to cooperation and collaborations.
The post-doctoral position at the Institut Pasteur, Paris, is for 12 months, renewable.
Starting dates are flexible, with a preference for beginning of December 2018.
Application, including a CV, two reference letters and detailed contacts, should be
sent by email to paola.arimondo@pasteur.fr

Closing date: October, 15th 2018
Contact: Paola B. Arimondo
Laboratory: Epigenetic Chemical Biology
Department of Structural Biology and Chemistry
28 rue Dr Roux
75724 Paris cedex 15
FRANCE
phone +33 1 40 61 32 91
email: paola.arimondo@pasteur.fr
website: https://research.pasteur.fr/en/member/paola-arimondo