We are looking for a young talented researcher to analyse neonatal immune response during severe pertussis and its role on the occurrence of the fulminant form of pertussis, through the investigations of the following aspects:
- Immune cell phenotyping of cord blood cells stimulated in vitro by pertussis
- Cytokines and chemokine secretion profiles
- Transcriptomic profiling of immune cells
- Functional studies of virulence genes on cellular infection models
Skills. Strong experience in immunology, with specific technical skills in flow cytometry and cellular biology. Experience in transcriptomics will be appreciated. Experience in Bordetella pathogenesis will be appreciated but is not absolutely required as it will be provided by members of the lab. Innovative thinking, work autonomy and good communication skills are important. English speaking and autonomous manuscript writing skills are also necessary.
Environment. The candidate will work in the Brisse lab at Institut Pasteur (https://research.pasteur.fr/en/team/biodiversity-and-epidemiology-of-bacterial-pathogens/), under the supervision of Dr. Julie Toubiana, Associate Professor in Pediatric Infectious Diseases and Deputy Head of Bordetella National Reference Center, and in collaboration with the Center for Translational Science (https://www.pasteur.fr/en/center-translational-science).
Conditions. The monthly salary will correspond to the standards in France and will depend on candidate experience. The contract will initially be for 12 months, but could be extended depending on grant applications outcome. The position is available as early as September 1st, 2018, although starting date can be delayed for a few months if the chosen candidate has agenda constraints.
Application: Please send your application as a single pdf to Julie Toubiana (firstname.lastname@example.org) with a detailed CV, a cover letter and recommendation letters. Deadline: July 1st, 2018.