One PhD position is available in the Dejean Laboratory, Nuclear Organisation and Oncogenesis Unit, at the Pasteur Institute in Paris, to decipher the role of SUMO in cellular plasticity and explore its implication in associated pathophysiological processes, with the ultimate goal of manipulating this pathway for translational purposes.
Cellular identity is dictated by large transcriptional programs mediated by specific chromatin configurations, yet the mechanisms by which cell fate transitions are normally constrained, or corrupted in disease, remain poorly understood. Identifying barriers to cellular plasticity is thus of key interest to dissect lineage choice mechanisms during development and has important clinical implications. While the contribution of DNA methylation and histone modifications during cell fate change has been extensively studied, the role of post-translational modifications of proteins by other proteins in this process is still enigmatic. Our lab has recently shown that, among these, SUMOylation is a key chromatin-associated mark that acts as a general safeguard of cellular identity. The project aims to clarify the role of SUMOylation in chromatin biology and cell plasticity and to analyze the possible impact of dysregulating this pathway in cancer and muscle regeneration.
Candidates should have solid background in molecular biology and biochemistry. Interest in in cancer biology or tissue repair will be a plus.
The appointments will be financed by an ERC Advanced Grant.
Applications including a cover letter with a brief statement of research experience, technical expertise and interests, a detailed CV and University transcripts, as well as contact details of two referees, should be sent to:
Anne Dejean, firstname.lastname@example.org