Thesis subject :Development of novel chemical assets targeting epigenetic regulation to
reprogram host-pathogen interactions in infectious diseases
Missions : The Ph.D thesis is interdisciplinary at the interface of chemistry and biology. The candidate
will be in charge of the synthesis and modulation of chemical molecules targeting the
epigenetic regulation and of biochemical, biophysical and cellular tests to evaluate the
biological activity of molecules.
Main activities : The main activities related to the project are: a medicinal chemistry activity involving
chemical synthesis, purification and chemical analysis; and a biology activity involving the
implementation and use of enzymatic and cellular tests and molecular biology techniques for
monitoring effects in cells.
Skills: The student must have knowledge of chemistry, biochemistry, molecular and cellular biology,
and be open to interface and collaborative projects.
The project is part of the challenge to fight antimicrobial resistance (AMR). Indeed, AMR is a
major health problem. For example, by 2050 routine surgical operations, for which today
patients are protected by antibiotic prophylaxis, will no longer be possible. It is known that
epigenetic regulation is involved in host-pathogen interactions and that the life cycles of
some pathogens are accompanied by significant epigenetic variations. Since epigenetic
changes are reversible, they can be modulated using chemical agents. The aim of the thesis
is to develop new molecules targeting DNA methylation and histones capable of acting on
pathogens and their infection. The project is based on collaboration with Biology units of the
Institut Pasteur working in the field of infectious diseases.
The thesis will take place in the Epigenetic Chemical Biology unit, which brings together
chemists and biologists dedicated to developing strategies to modulate the epigenetic
regulation and reprogram cancer cells, and, in collaboration, infected cells or pathogens. The
unit is part of the CNRS-Pasteur Institute Joint Unit (UMR n°3523) and is located in the
Institut Pasteur in Paris. The Campus brings together many research units dedicated to AMR
and epigenetics, which privileges interactions and interdisciplinary projects. The student will
have the opportunity to do some of his or her research at the Department of Organic
Chemistry at Oxford University, England.
Duration and Starting date
Starting date 1st October 2019 for a period of 3 years.
Application, including a CV, two reference letters and detailed contacts, should be sent by
email to email@example.com
Closing date: September, 30th 2019
Contact: Paola B. Arimondo, Epigenetic Chemical Biology, CNRS UMR3523
Institut Pasteur, 28 rue Dr Roux, 75724 Paris cedex 15, FRANCE