Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.
Job

Looking for postdoctoral candidates in biochemistry and biophysics to investigate proteins and membranes

Scientific Fields
Diseases
Organisms
Applications
Technique
Application Deadline
21
Aug 2016
2016-08-21 8:00:00 2016-08-21 18:00:00 Europe/Paris Looking for postdoctoral candidates in biochemistry and biophysics to investigate proteins and membranes We are looking for postdoctoral candidates interested to apply for a MSCA IF EF-ST funding on molecular crowding effects on protein – protein interactions and protein membrane interactions. Motivated, team-spirited young or confirmed post-doc […] "25-28 rue du Dr. Roux, 75015, Paris" Alexandre Chenal alexandre.chenal@pasteur.fr

We are looking for postdoctoral candidates interested to apply for a MSCA IF EF-ST funding on molecular crowding effects on protein – protein interactions and protein membrane interactions. Motivated, team-spirited young or confirmed post-doc fellows can apply. MSCA IF EF-ST funding is more dedicated to post-doc fellows (for a 2d, 3d or 4th post-doc position) than for a first post-doc just after a PhD. Young French scientists or people who already worked in France are not eligible (see MSCA guidelines, more precisely MSCA IF EF-ST: Marie Skłodowska-Curie Action Individual Fellowships Standard European Fellowships). A critical point is the publication list, including first author articles in international peer-reviewed journal.

Deadline: send emails until the 21st August; submission deadline to MSCA: 15th September 2016

Project title: Protein behavior in crowded environment: Effect of molecular crowding on ligand-binding, protein-protein and protein-membrane interactions

Keywords: Molecular crowding; adenylate cyclase CyaA toxin; protein ligand interaction; protein membrane interaction; protein folding and stability

Project: Macromolecular crowding is a characteristic of all living organisms: biological fluids and cells are composed of a large variety of macromolecules that together occupy a significant fraction (10–40%) of the volume. The resulting steric exclusion, since a fraction of the space is physically inaccessible to other molecules, has consequences on both rates and equilibria of biochemical reactions, and consequently favors the conformations that occupy less molecular volume. For instance, crowded environments affect proteins as they experience volume restrictions due to the surrounding macromolecules, thus favoring (i) the most compact and stable conformations of proteins, (ii) multimerization between proteins, (iii) increasing protein-ligand affinity and (iv) membrane interactions. Hence, the physico-chemistry of proteins in crowded environments is expected to mimic in vivo conditions and to be markedly different than those in dilute solutions in vitro. In this application, we propose to investigate the effect of molecular crowding on the successive steps of the intoxication process of the CyaA toxin, which offers the opportunity to evaluate the impact of the four properties mentioned above. Besides basic sciences, the expected outputs will be instrumental to improve the CyaA-based biotechnological applications developed in the Unit.