The Statistical Genetics unit within the Department of Computational Biology at the Institut Pasteur seeks a motivated junior research engineer. The successful candidate will participate in an ongoing collaborative project aiming at deepening our understanding of human genetics.
To this day, a vast number of GWAS (Genome Wide association Studies that is an analysis mapping genetic variations affecting a trait) has been performed and their results made available to the research community. For instance the EBI GWAS catalog contains as many as 10000 GWAS results for a variety of traits going from psychiatric illnesses to cholesterol dosage. Here at the Institut Pasteur statistical genetic group, we are especially interested in pleiotropy (i.e. the fact a variant can affect several traits at once). We recently built several computational tools including a website to study the effect of variants across phenotypes.
Currently, our database contains 154 GWAS results for European ancestry individuals. We would like to enrich our database in two ways: increase the number of traits available, include traits measured on individuals of other ancestry (African, Asian, …).
The main topic of this short contract will be to contribute to this effort. The successful applicant will be asked to (with the help of the supervising team):
- Download and curate GWAS publicly available results
- Apply and maintain a cleaning pipeline on the downloaded results
- Make the results available on the jass.pasteur.fr website
The position mostly has a computational component with a particular emphasis on scripting.
THE INSTITUT PASTEUR
The Institut Pasteur is an internationally renowned center for biomedical research that stands out in many disciplines. The campus, founded in 1887 by Louis Pasteur and located in the center of Paris, hosts over 1,300 researchers and 300 doctoral students from over 60 nationalities. It is a creative and inspiring environment full of expertise and opportunities to connect and learn. The department of Computational Biology hosts multiple teams and a biostatistics/bioinformatics hub which includes over 50 PhD engineers specialized in computational biology.
More information on the Institut Pasteur and the Statistical Genetics unit can be found here http://www.pasteur.fr/en and here https://research.pasteur.fr/en/team/statistical-genetics/.
Applicants may start in January-February 2022 and applications will be considered until the end of December 2021.