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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Event

Virology Department Seminar: “Mechanism of epigenetic variability in clonal cell lineages” with Alexander Gimelbrant

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
06
Nov 2019
Time
14:00:00
28 Rue du Docteur Roux, Paris, France
Address
Building: Centre François Jacob
Location
2019-11-06 14:00:00 2019-11-06 15:00:00 Europe/Paris Virology Department Seminar: “Mechanism of epigenetic variability in clonal cell lineages” with Alexander Gimelbrant VIROLOGY DEPARTMENT SEMINAR   Prof. Alexander GIMELBRANT  Dana-Farber Cancer Institute Harvard Medical School Broad Institute of Harvard and MIT   “Mechanism of epigenetic variability in clonal cell lineages”    Mercredi 6 Novembre 2019 à […] 28 Rue du Docteur Roux, Paris, France Yves Jacob yves.jacob@pasteur.fr

About

VIROLOGY DEPARTMENT SEMINAR

 

Prof. Alexander GIMELBRANT

 Dana-Farber Cancer Institute
Harvard Medical School
Broad Institute of Harvard and MIT

 

“Mechanism of epigenetic variability in clonal cell lineages”

 

 Mercredi 6 Novembre 2019 à 14h00

  Auditorium du Centre François Jacob

  

Invited by: Dr Yves Jacob (yves.jacob@pasteur.fr)   

 Institut Pasteur – 28, rue du Dr. Roux – 75724 PARIS CEDEX 15

  Abstract:

“In mammals, otherwise similar cells from distinct clonal lineages can maintain striking epigenetic differences, with profound impact on transcription and cell function. Inactivation of one copy of the X chromosome in female cells is the best understood example of such epigenetic mosaicism. Autosomal monoallelic expression (MAE) is another common example, with different clonal lineages maintaining distinct states of allele-specific expression. Despite its prevalence, no molecular mechanisms underlying MAE have been identified to date. We developed and applied a new screening-by-sequencing strategy to identify mechanism of mitotic memory of MAE in clonal mouse cells. Contrary to previous reports, DNA methylation plays key role in mitotic memory of MAE in multiple autosomal loci.

Building on this finding, we performed the first genome-wide analysis of changes in allele-specific gene-regulatory landscape in response to chemical perturbation. Unexpectedly, genome-wide changes were not limited to relaxation of MAE towards equal biallelic expression. Many genes showed paradoxical increase of allelic imbalance, even though it relaxed for DNA methylation and chromatin accessibility. These unexpected observations are explained by comparative analysis of multiple clonal lines, revealing a previously unappreciated interplay of genetic regulatory architecture with epigenetic control of allele-specific expression.”

 

Location

Building: Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France