Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Event

Seminar Mycology Dpt: Falk Hillman ( Hans Knöll Institute, Jena, Germany);”Amoebae as evolutionary models for fungal virulence and phagocytic processing” ; JP Aubert room, Fernbach Building.

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
21
Apr 2022
Time
12:00:00
25 Rue du Docteur Roux, Paris, France
Address
2022-04-21 12:00:00 2022-04-21 13:00:00 Europe/Paris Seminar Mycology Dpt: Falk Hillman ( Hans Knöll Institute, Jena, Germany);”Amoebae as evolutionary models for fungal virulence and phagocytic processing” ; JP Aubert room, Fernbach Building. Amoebae as evolutionary models for fungal virulence and phagocytic processing Falk Hillmann1,2 1Independent Junior Research Group – Evolution of Microbial Interactions, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, […] 25 Rue du Docteur Roux, Paris, France Vishu Kumar Aimanianda Bopaiah kumar-vishu.aimanianda-bopaiah@pasteur.fr

About

Amoebae as evolutionary models for fungal virulence and phagocytic processing

Falk Hillmann1,2

1Independent Junior Research Group – Evolution of Microbial Interactions, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

2Faculty of Engineering, Hochschule Wismar, University of Applied Sciences, Technology, Business and Design, Wismar, Germany

Free living amoebae share striking similarities with innate immune cells in terms of cell morphology, motility and phagocytic processing of microbes. Moreover, their abilities to find ingest and kill microbes in their natural habitats have fostered the hypothesis that amoebae could have served as a training ground for environmentally acquired pathogens. What may have been more obvious for intracellular bacteria and fungi becomes increasingly clear also for several fungal pathogens: Here, I will show that a number of virulence determinants even from the genus Candida or the filamentous fungus Aspergillus fumigatus are equally relevant to resist innate immune cells and environmental phagocytic predators. We recently isolated the fungus specific predator Protostelium aurantium, an amoeba which is widespread in terrestrial habitats and feeds exclusively on fungi. The amoeba ingests and kills a wide range of fungal pathogens including several basidiomycetous yeast and members of the Candida clade. However, C. albicans and C. glabrata, were efficiently protected, either due to extensive mannoprotein coating of the cell surface or the use of short chain ubiquinone cofactors, respectively.  When encountering fungal hyphae such as those of A. fumigatus, the amoeba switched from phagocytosis to ruphocytosis, meaning that the fungal hyphae were actively invaded, and the entire cytoplasm was resorbed within minutes. Phagocytic studies with immunologically inert conidia showed that the uptake of melanized conidia was generally avoided and led to prolonged intracellular retention, finally causing enhanced damage to the amoeba phagolysosomal membrane. Our results indicate that several known virulence attributes actually serve a dual role by providing protection against environmental predators and may be under significant selective pressure in natural habitats.

 

Location

Address: 25 Rue du Docteur Roux, Paris, France