Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Clinical Research Assistant
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Clinical Research Assistant
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Event

Pr Christian LEUMANN -University of Bern- “A revival of bicyclo-DNA”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
07
Sep 2017
Time
14:00:00
25 Rue du Dr Roux, Paris, France
Address
Room: Salle JULES BORDET - Metchnikoff RdC 45
Location
2017-09-07 14:00:00 2017-09-07 19:00:00 Europe/Paris Pr Christian LEUMANN -University of Bern- “A revival of bicyclo-DNA” Séminaire du Département de Biologie Structurale & Chimie   Jeudi 7 Septembre 2017 à 14h00 Salle JULES BORDET – Metchnikoff RdC 45   Pr Christian LEUMANN University of Bern   A revival of bicyclo-DNA […] 25 Rue du Dr Roux, Paris, France

About

Séminaire du Département de Biologie Structurale & Chimie

 

Jeudi 7 Septembre 2017 à 14h00

Salle JULES BORDET – Metchnikoff RdC 45

 

Pr Christian LEUMANN

University of Bern

 

A revival of bicyclo-DNA

 In the early nineties we introduced the concept of conformational restriction with the example of bicyclo-DNA (bc-DNA), resulting in oligonucleotide structures the show reduced entropic penalty upon duplex formation. This concept has been adapted by others and has produced excellent oligonucleotide drug candidates such as locked-nucleic acids (LNA) and hexitol nucleic acids (HNA).These analogues typically exhibit increased affinity to RNA and feature higher nuclease resistance.

While in this way the challenges linked to target affinity and nuclease resistance have largely been met, other requirements such as improving cellular uptake and distribution are yet elusive. In the context of oligonucleotide therapeutics our laboratory has developed over the years the bicyclo-DNA molecular platform. The 5-membered carbocyclic ring in bicyclo-DNA offers unique possibilities for further chemical modification, specifically at C(6’) and C(7’), to introduce additional functional groups for various purposes. In recent work we reported on the DNA and RNA affinity of oligonucleotides containing 7ˈ,5ˈ-bicyclo-nucleoside units. We have also investigated the properties of the corresponding 7ˈ,5ˈ-bicyclo-nucleoside triphosphate as a potential XNA candidate to generate modified aptamers.

 

Contact: Marcel HOLLENSTEIN / DBSC

marcel.hollenstein@pasteur.fr

Location

Room: Salle JULES BORDET - Metchnikoff RdC 45
Address: 25 Rue du Dr Roux, Paris, France