About
NEUROSCIENCE SEMINAR SERIES
Friday, October 09th at 10 am on Microsoft Teams
Dr. Gabrielle GIRARDEAU
Team “Sommeil et Mémoire Émotionnelle”
Institut du Fer-à-Moulin, UMR-S 1270 Inserm – Sorbonne Université
“Neural mechanisms for memory and emotional processing during sleep”
Invited by : Mathlide Bigot
Abstract :
The hippocampus and the amygdala are two structures required for emotional memory. While the hippocampus encodes the contextual part of the memory, the amygdala processes its emotional valence. During Non-REM sleep, the hippocampus displays high frequency oscillations called “ripples”. Our early work shows that the suppression of ripples during sleep impairs performance on a spatial task, underlying their crucial role in memory consolidation. We more recently showed that the joint amygdala-hippocampus activity linked to aversive learning is reinstated during the following Non-REM sleep epochs, specifically during ripples. This mechanism potentially sustains the consolidation of aversive associative memories during Non REM sleep. On the other hand, REM sleep is associated with regular 8 Hz theta oscillations, and is believed to play a role in emotional processing. A crucial, initial step in understanding this role is to unravel sleep dynamics related to REM sleep in the hippocampus-amygdala network.
Location
Room: on TEAMS
Address: Pasteur Institute, Rue du Docteur Roux, Paris, France