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© Research
Event

“Interleukin-17-mediated host defense against fungal infections”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
04
Sep 2017
Time
14:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Fernbach RdC Room: Jean-Paul Aubert
Location
2017-09-04 14:00:00 2017-09-04 15:00:00 Europe/Paris “Interleukin-17-mediated host defense against fungal infections” Salomé LeibundGut-Landmann – University of Zürich, Switzerland Fungal pathogens bear a serious health hazard for individuals with a weakened immune system. Although some fungi, such as Candida albicans, are present in the normal human […] Institut Pasteur, Rue du Docteur Roux, Paris, France Jessica Quintin jessica.quintin@pasteur.fr

About

Salomé LeibundGut-Landmann – University of Zürich, Switzerland

Fungal pathogens bear a serious health hazard for individuals with a weakened immune system. Although some fungi, such as Candida albicans, are present in the normal human microbiota, they can cause severe diseases if host defenses are breached. The continuous rise in fungal infections and the increase in resistance against available antifungal drugs urge the development of novel preventive and therapeutic strategies. For this, a detailed understanding of fungal pathogenicity and natural host defense mechanisms is of great importance. It is generally believed that the host immune status determines the outcome of the interaction between the fungus and the host, resulting in health or disease. Specific host mechanisms including those mediated by the cytokine interleukin-17 are now known to regulate the antimicrobial response and thereby limit fungal overgrowth at the epithelial barriers. It remains less clear however how the genetic diversity of C. albicans that is detected in strains isolated from colonized individuals impacts on the outcome of the interaction of the fungus with its host. Here I will discuss the current view of dynamic host-pathogen interactions that adjust the fine balance between fungal colonization and pathogenic infection.

http://www.vetvir.uzh.ch/en/Research/Immunology.html

Contact : Jessica Quintin (jessica.quintin@pasteur.fr – Poste : 9454)

Location

Building: Fernbach RdC
Room: Jean-Paul Aubert
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France