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© Research
Event

DSCB Seminar – Dr. Moises Mallo, GIMM – Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal – “The early life of Tgfbr1: Molding legs and genitals”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
07
Feb 2025
Time
11:00:00
25 Rue du Docteur Roux, Paris, France
Address
Building: Monod Room: Amphi Ullmann
Location
2025-02-07 11:00:00 2025-02-07 12:00:00 Europe/Paris DSCB Seminar – Dr. Moises Mallo, GIMM – Gulbenkian Institute for Molecular Medicine, Oeiras, Portugal – “The early life of Tgfbr1: Molding legs and genitals” Abstract: The transforming growth factor receptor 1 (Tgfbr1) is widely known for its multiple roles in physiological and pathological activities, including maintaining immune homeostasis, promoting stem cell activity, tissue repair and regeneration, and its […] 25 Rue du Docteur Roux, Paris, France Shahragim Tajbakhsh shahragim.tajbakhsh@pasteur.fr

About

Abstract:

The transforming growth factor receptor 1 (Tgfbr1) is widely known for its multiple roles in physiological and pathological activities, including maintaining immune homeostasis, promoting stem cell activity, tissue repair and regeneration, and its involvement in tumorigenesis. I will show here that before all those activities, this receptor plays an essential role during development organizing the outlets of the digestive, excretory and genital systems and promoting formation of the hindlimbs and external genitalia. I will also show that in the absence of Trgfr1 the genitals are converted to legs, uncovering a remarkable plasticity of the genital and hindlimb primordia that might have played a role in vertebrate evolution. I will discuss our data indicating that Tgfbr1 controls this plasticity by regulating the regulatory landscape of the tissue. These findings might have deep implications to understand not only vertebrate development and evolution, but also how Tgfbr1 controls other physiological and pathological processes in which it is involved.

Hosted by Shahragim Tajbakhsh

shahragim.tajbakhsh@pasteur.fr

Location

Building: Monod
Room: Amphi Ullmann
Address: 25 Rue du Docteur Roux, Paris, France