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© Research
Event

Dr Peter J. BOND – “Multiscale Simulations Help Map Flavivirus Fusion Dynamics”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
07
Sep 2017
Time
12:00:00
28 Rue du Docteur Roux, Paris, France
Address
Room: Auditorium du Centre F. Jacob
Location
2017-09-07 12:00:00 2017-09-07 19:00:00 Europe/Paris Dr Peter J. BOND – “Multiscale Simulations Help Map Flavivirus Fusion Dynamics” Séminaire du Département de Biologie Structurale & Chimie   Jeudi 7 Septembre 2017 à 12 h Auditorium du Centre F. Jacob Dr Peter J. BOND Bioinformatics Institute (A*STAR), Matrix 07-01, 30 Biopolis Street, Singapore […] 28 Rue du Docteur Roux, Paris, France

About

Séminaire du Département de Biologie Structurale & Chimie

 

Jeudi 7 Septembre 2017 à 12 h

Auditorium du Centre F. Jacob

Dr Peter J. BOND

Bioinformatics Institute (A*STAR), Matrix 07-01, 30 Biopolis Street, Singapore 138671 (Singapore)

Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 (Singapore)

Multiscale Simulations Help Map Flavivirus Fusion Dynamics

The positive single-stranded RNA flaviviruses are primary causative agents of infectious disease. Members include dengue virus and the emerging pathogens such as Zika. The viral nucleocapsid core is encapsulated by a phospholipid bilayer, within which are embedded envelope and membrane proteins. Low pH conditions trigger conformational changes in the envelope protein and exposure of the highly conserved fusion peptide (FP) region, which is critical for membrane fusion and represents a significant target for antiviral drugs and antibodies. I will give an overview of our recent progress in understanding the role of the FP in virus-host interactions, via a combination of integrative modelling, multiscale simulations, and biophysical studies.

Contact : O. FRANCETIC / Unité de Biochimie des Interactions Macromoléculaires

Olivera.francetic@pasteur.fr

–––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––INSTITUT PASTEUR - 28, rue du Docteur Roux – 75015 Paris

Location

Room: Auditorium du Centre F. Jacob
Address: 28 Rue du Docteur Roux, Paris, France